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Mechanical Roles of Vinculin/β-catenin interaction in Adherens Junction
(2019)
Mechanical force transmission through the adherens junctions (AJs) are highly regulated processes essential for multicellular organization of tissues. AJ proteins such as E-cadherin, α-catenin, and vinculin have been shown ...
The first armadillo repeat is involved in the recognition and regulation of β-catenin phosphorylation by protein kinase CK1
(2006)
Multiple phosphorylation of β-catenin by glycogen synthase kinase 3 (GSK3) in the Wnt pathway is primed by CK1 through phosphorylation of Ser-45, which lacks a typical CK1 canonical sequence. Synthetic peptides encompassing ...
In vitro studies revealed a downregulation of Wnt/β-catenin cascade by active vitamin D and TX 527 analog in a Kaposi's sarcoma cellular model
(Pergamon-Elsevier Science Ltd, 2020-03)
The Kaposi´s sarcoma-associated herpesvirus G-protein-coupled receptor (vGPCR) is a key molecule in the pathogenesis of Kaposi´s sarcoma. We have previously demonstrated that 1α,25(OH)2D3 or its less calcemic analogTX 527 ...
Attenuation of the Wnt/b-catenin/TCF pathway by in vivo interferon-a2b (IFN-a2b) treatment in preneoplastic rat livers
(Taylor & Francis, 2010)
Wnt/β-catenin/T cell factor (TCF) pathway is activated in several types of human cancers, promoting cell growth and proliferation. Forkhead box containing protein class O (FOXO) transcription factors compete with TCF for ...
CK2 functionally interacts with AKT/PKB to promote the β-catenin- dependent expression of survivin and enhance cell survival
(2011)
β-Catenin is crucial in the canonical Wnt signaling pathway. This pathway is up-regulated by CK2 which is associated with an enhanced expression of the antiapoptotic protein survivin, although the underlying molecular ...
Phosphorylation of AKT/PKB by CK2 is necessary for the AKT-dependent up-regulation of β-catenin transcriptional activity
(2011)
β-Catenin is a key protein in the canonical Wnt signaling pathway and in many cancers alterations in transcriptional activity of its components are observed. This pathway is up-regulated by the protein kinase CK2, but the ...
Efeito α-tomatina na proliferação celular, apoptose e expressão de RNAm dos genes APC, Ciclina A2, Catenina, CASP9, BAK, BAX e BCL-XL em células HT29
(Universidade Estadual Paulista (UNESP), 2014)
Role of wnt/beta-catenin signaling in ovarian tumour growth and angiogenesis. A crosstalk with Notch system
(Instituto de Histología y Embriología, 2019)
Wnt/β-catenin and Notch are highly conserved pathways that regulate a diversity of cell processes, including proliferation, apoptosis and differentiation. We analyzed the role of both systems in ovarian cancer using specific ...