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Models for evaluating the pharmacokinetics and pharmacodynamics for β-blockers
(Informa Healthcare, 2014-04)
Introduction: β-blocker therapy plays an important role in the treatment of various diseases, including hypertension, myocardial infarction and heart failure. Although all β-blockers shared their ability to competitively ...
Issues in drug metabolism of major antihypertensive drugs: β-blockers, calcium channel antagonists and angiotensin receptor blockers
(Taylor & Francis, 2010-01)
Several first-line antihypertensive drugs, including calcium channel blockers, beta-adrenergic blockers and angiotensin receptor blockers, undergo metabolism through different CYP isoforms. As a consequence of CYP-dependent ...
A comparison of the effects of the selective peripheral α1-blocker terazosin with the selective β1-blocker atenolol on blood pressure, exercise performance and the lipid profile in mild-to-moderate essential hypertension
(Springer-Verlag, 1992)
The effects of six weeks of treatment with the selective peripheral α1-adrenoceptor blocker terazosin, or the selective β1-adrenoceptor blocker atenolol on blood pressure, exercise performance and blood lipid profile were ...
Factors influencing hepatic metabolism of antihypertensive drugs: impact on clinical response
(Informa Healthcare, 2019-01)
Introduction: Although main antihypertensive drugs are able to efficiently reduce blood pressure, only a third of treated hypertensive patients achieve optimal blood pressure control. Extensive interpatient variability on ...
Interaction of α- and β-Adrenergic Receptor Blocking Agents in the Conscious Rat
(Informa Healthcare, 1979-01-01)
In a commentary in this journal by Oates (2) on our work on interactions of α- and β-blockers (1), the author confirms our results; i.e. β-blockers (β2) block the α-blocker induced hypotension in conscious rats. However, ...
Study of enantioseparation of β-blockers using amylose tris(3-chloro-5-methylphenylcarbamate) as chiral stationary phase under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions
(Elsevier, 2020-12)
In this study, we describe the experimental variables influencing enantioseparation of twelve β-blockers when analyzed under polar-organic, reversed-phase and hydrophilic interaction liquid chromatography conditions on a ...
Acute effects of third generation β-blockers on short-term and beat-to-beat blood pressure variability in sinoaortic-denervated rats
(Nature Publishing Group, 2013-04)
An increase in blood pressure variability (BPV) contributes to the development of target organ damage associated with hypertension. Treatment with conventional b-blockers, such as atenolol, has been associated with an ...
Efeitos dos betas-bloqueadores na sepse em camundongos
(Universidade Estadual Paulista (Unesp), 2020-05-15)
Introdução: Sepse é uma das mais antigas síndromes reconhecidas na história da medicina. Atualmente, é descrita como uma resposta inflamatória sistêmica desregulada do hospedeiro à infecção que ocasiona diversos comprometimentos ...
The influence of adrenergic blockade in rats with apical periodontitis under chronic stress conditions
(2020-02-01)
Objective: To investigate the influence of chronic stress and adrenergic blockade in a rat model of apical periodontitis. Methods: Thirty-two Wistar rats were submitted to an animal model of periapical lesion and randomly ...