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Mirabegron relaxes urethral smooth muscle by a dual mechanism involving β3-adrenoceptor activation and α1-adrenoceptor blockade
(Wiley Online Library, 2015)
Mirabegron is the first β3-adrenoceptor (AR) agonist approved for treatment of overactive bladder syndrome (OAB). This study aimed to investigate the effects of β3-adrenoceptor (AR) agonist mirabegron in mouse urethra. The ...
8-NH2-boldine, an antagonist of α1A and α1B adrenoceptors without affinity for the α1D subtype: Structural requirements for aporphines at α1- adrenoceptor subtypes
(2005)
Structure-activity analysis of 21 aporphine derivatives was performed by examining their affinities for cloned human α1A, α1B and α1D adrenoceptors (AR) using membranes prepared from rat-1 fibroblasts stably expressing ...
Investigação do envolvimento de subtipos de adrenoceptores α1 no efeito anti-imobilidade da imipramina no teste de suspensão pela cauda
(Universidade Estadual Paulista (Unesp), 2015-02-27)
Imipramine is a tricyclic antidepressant inhibitor of norepinephrine and serotonin neuronal reuptake. In addition, the imipramine antagonizes α1-adrenoceptors in the same concentration range that inhibited norepinephrine ...
Effect of inter-renal aortic coarctation-induced hypertension on function and expression of vascular α1A- and α1D-adrenoceptors
(National Research Council of Canada, 2012-01)
We investigated the effect of inter-renal aortic coarctation on the function and expression of vascular a1A- and a1D-adrenoceptors and plasma angiotensin II (ATII) in rats. Male Wistar rats, either sham operated (SO), or ...
α-Adrenoceptor and opioid receptor modulation of clonidine-induced antinociception
(John Wiley and Sons Inc., 1996)
1. The antinociceptive action of clonidine (Clon) and the interactions with α1, α2 adrenoceptor and opioid receptor antagonists was evaluated in mice by use of chemical algesiometric test (acetic acid writhing test). 2. ...
Updates in the function and regulation of α1-adrenoceptors
(2019-07-01)
α1-Adrenoceptors are seven transmembrane domain GPCRs involved in numerous physiological functions controlled by the endogenous catecholamines, noradrenaline and adrenaline, and targeted by drugs useful in therapeutics. ...
Expressão e caracterização farmacológica dos subtipos de adrenoceptores α1 na cauda proximal e distal do epidídimo de rato
(Universidade Estadual Paulista (Unesp), 2012-06-12)
O epidídimo é um órgão formado por um longo túbulo enovelado composto por 3 regiões anatômicas distintas: a cabeça, o corpo e a cauda. A cabeça e o corpo do epidídimo têm papel na maturação dos espermatozóides, enquanto ...
Expressão e caracterização farmacológica dos subtipos de adrenoceptores α1 na cauda proximal e distal do epidídimo de rato
(Universidade Estadual Paulista (Unesp), 2012-06-12)
O epidídimo é um órgão formado por um longo túbulo enovelado composto por 3 regiões anatômicas distintas: a cabeça, o corpo e a cauda. A cabeça e o corpo do epidídimo têm papel na maturação dos espermatozóides, enquanto ...