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Mostrando ítems 81-90 de 341
Esferoides como modelo predictivo de respuesta tumoral a la terapia génica : Estudio de los efectos de la transferencia génica no viral del sistema gen suicida y del gen de interferón-beta en esferoides derivados de melanoma espontáneo caninoSpheroids as a predictive model to study the tumor response to gene therapy : Study of the effects of the non viral gene transfer of the suicide gene system and the interferon-beta gene on spheroids derived from spontaneous canine melanoma
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2011)
Síntesis de un lípido catiónico derivado de un aminoácido básico y su caracterización química y biológica para la transferencia de genes
(Universidad Autónoma Metropolitana (México). Unidad Azcapotzalco. División de Ciencias Básicas e Ingeniería., 2015)
La terapia génica es una estrategia terapéutica basada en la modificación del repertorio genético de las células mediante la administración de ácidos nucleicos. La principal limitante de su aplicación in vivo es la dificultad ...
Tumor venéreo transmissível canino: expressão de genes relacionados com o comportamento biológico e microambiente tumoral
(Universidade Estadual Paulista (Unesp), 2016-12-01)
O tumor venéreo transmissível (TVT) é um câncer transmissível, que propaga-se naturalmente entre os cães, pela transferência alogênica de células tumorais, principalmente, durante o coito. Sabe-se que o microambiente tumoral ...
Development of a recombinant fusion protein based on the dynein light chain LC8 for non-viral gene delivery
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
The low efficiency of gene transfer is a recurrent problem in DNA vaccine development and gene therapy studies using non-viral vectors such as plasmid DNA (pDNA). This is mainly due to the fact that during their traffic ...
alpha-L-iduronidase gene-based therapy using the phiC31 system to treat mucopolysaccharidose type I mice
(Wiley-Blackwell, 2015-01-01)
BackgroundMucopolysaccharidose type I (MPSI) is a lysosomal monogenic disease caused by mutations in the gene for - l-iduronidase (IDUA). MPSI patients need a constant supply of IDUA to alleviate progression of the disease. ...
Efeitos in vivo e in vitro da cafeína sobre a diferenciação osteogênica das células tronco mesenquimais e atividade de síntese de osteoblastos e condrócitos de ratos
(Universidade Federal de Minas GeraisUFMG, 2017-01-13)
Caffeine is an active alkaloid that can cause damage to bone tissue and cartilage in formation during prenatal life and into adulthood. This compound is transfered to offspring through the placenta and milk, causing a ...
Spontaneous Mutations in the Nitrate Reductase Gene napC Drive the Emergence of Eco-friendly Low-N2O-Emitting Alfalfa Rhizobia in Regions with Different Climates
(Springer, 2020)
We have recently shown that commercial alfalfa inoculants (e.g., Sinorhizobium meliloti B399), which are closely related to the denitrifier model strain Sinorhizobium meliloti 1021, have conserved nitrate, nitrite, and ...