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Thrombotic microangiopathy after kidney transplantation: Analysis of the Brazilian Atypical Hemolytic Uremic Syndrome cohort
(2021-11-01)
Background Atypical Hemolytic Uremic Syndrome (aHUS) is an ultra-rare disease that potentially leads to kidney graft failure due to ongoing Thrombotic Microangiopathy (TMA). The aim was evaluating the frequency of TMA after ...
Desfechos da descontinuidade não planejada do eculizumabe na síndrome hemolítico urêmica atípica após escassez no Brasil
(Universidade Estadual Paulista (Unesp), 2021-08-06)
O risco da descontinuação da terapia com eculizumabe em pacientes com Síndrome Hemolítico Urêmica Atípica (SHUa) ainda não é claro. O principal objetivo deste estudo foi analisar o risco de recidiva de SHUa após a ...
Shiga toxin 1-induced inflammatory response in lipopolysaccharide- sensitized astrocytes is mediated by endogenous tumor necrosis factor alpha
(American Society for Microbiology, 2010-03)
Hemolytic-uremic syndrome (HUS) is generally caused by Shiga toxin (Stx)-producing Escherichia coli. Endothelial dysfunction mediated by Stx is a central aspect in HUS development. However, inflammatory mediators such as ...
Retinoid levels influence enterohemorrhagic Escherichia coli infection and shiga toxin susceptibility in mice
(American Society for Microbiology, 2014-09)
Enterohemorrhagic Escherichia coli (EHEC) is a food-borne pathogen that produces Shiga toxin (Stx) and causes hemorrhagic colitis. Under some circumstances, Stx produced within the intestinal tract enters the bloodstream, ...
A recombinant O-polysaccharide-protein conjugate approach to develop highly specific monoclonal antibodies to Shiga toxin-producing Escherichia coli O157 and O145 serogroups
(Public Library of Science, 2017-10)
Shiga toxin-producing Escherichia coli (STEC) is the major etiologic agent of hemolytic-uremic syndrome (HUS). The high rate of HUS emphasizes the urgency for the implementation of primary prevention strategies to reduce ...