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Mostrando ítems 81-90 de 204
Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts
(Frontiers Media S.A., 2019-07-18)
Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid-ordered microdomains (raft domains), ...
Interleukin-3 prevents neuronal death induced by amyloid peptide
(BIOMED CENTRAL LTD, 2007-10-03)
Background: Interleukin-3 (IL-3) is an important glycoprotein involved in regulating biological
responses such as cell proliferation, survival and differentiation. Its effects are mediated via
interaction with cell surface ...
New mimetic peptides inhibitors of Аb aggregation. Molecular guidance for rational drug design
(Elsevier, 2015-05)
A new series of mimetic peptides possessing a significant Aβ aggregation modulating effect was reported here. These compounds were obtained based on a molecular modelling study which allowed us to perform a structural-based ...
Insulin-degrading enzyme: Structure-function relationship and its possible roles in health and disease
(Bentham Science Publishers, 2009-11)
Insulin-degrading enzyme (IDE) or insulysin is a highly conserved Zn 2+-dependent endopeptidase with an "inverted" HxxEH motif. In vivo, IDE contributes to regulate the steady state levels of peripheral insulin and cerebral ...
Nanopartículas plasmónicas para la detección de agregados del péptido β-amiloide mediante fluorescencia aumentada por superficie
(Universidad de Chile, 2020)
Una de las hipótesis más aceptada para la etiología de la enfermedad de Alzheimer (EA) es
la “hipótesis de la cascada amiloide”. Esta hipótesis se centra en la acumulación de
agregados tóxicos del péptido β-amiloide (Aβ), ...
Curvature Effect of functionalized gold nanoparticles and their influence on the amyloid beta peptide aggregationEfecto de la curvatura de nanopartículas de oro funcionalizadas y su influencia sobre la agregación del péptido B-Amoloide
(2021)
La enfermedad de Alzheimer (EA) es una de las patologías neurodegenerativas más importantes y una de las formas más comunes de demencia. Esta enfermedad se caracteriza por presentar el proceso de agregación del péptido β ...
Decrease of ERK/MAPK overactivation in prefrontal cortex reverses early memory deficit in a mouse model of Alzheimer's disease
(Ios Press, 2013-11)
Alzheimer's disease (AD) can be considered as a disease of memory in its initial clinical stages. Amyloid-β (Aβ) peptide accumulation is central to the disease initiation leading later to intracellular neurofibrillary ...
Memory recovery through gene therapy with a single chain antibody fragment selective for Aβ oligomers in a model of Alzheimer’s disease in ratsRecuperación de la memoria mediante terapia génica con un fragmento de anticuerpo selectivo para oligómeros de Aβ en un modelo de Alzheimer en ratas
(Corporación Universidad de la CostaColombia, 2023)
Amyloid-β precursor protein modulates the sorting of testican-1 and contributes to its accumulation in brain tissue and cerebrospinal fluid from patients with Alzheimer disease
(Lippincott Williams and WilkinsFacultad de Ciencias NaturalesDepartamento de Ciencias Biológicas, 2016-01-01)
The mechanisms leading to amyloid-β (Aβ) accumulation in sporadic Alzheimer disease (AD) are unknown but both increased production or impaired clearance likely contribute to aggregation. To understand the potential roles ...
Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition
(BioMed Central, 2018-02)
Background: The phosphodiesterase (PDE) 7 inhibitor S14 is a cell-permeable small heterocyclic molecule that is able to cross the blood-brain barrier. We previously found that intraperitoneal treatment with S14 exerted ...