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Human chromosome aberrations induced in vitro by Paracoccidioides brasiliensis glycoproteic component (GP 43)
(1997-04-24)
The in vitro cytogenetic effects of the 43-kDa molecular mass exocellular glycoproteic component (GP 43) from Paracoccidioides brasiliensis were studied in cultures from human lymphocytes. The sample included 10 healthy, ...
Plant extracts and betulin from Ligaria cuneifolia inhibit P-glycoprotein function in leukemia cells
(Pergamon-Elsevier Science Ltd, 2020-12)
Overexpression of P-glycoprotein (P-gp), which is linked to multidrug resistance (MDR), is one of the underlying obstacles to the success of chemotherapy as it reduces the efficacy of anticancer drugs and the side effects ...
P-glycoprotein expression and pharmacological modulation in larval stages of Echinococcus granulosus
(Elsevier Ireland, 2014-02)
P-glycoprotein (Pgp) is an ATP-dependent transporter involved in the efflux of a wide variety of lipophilic substrates, such as toxins and xenobiotics, out of cells. Pgp expression level is associated with the ineffective ...
The role of glycosylated epitopes in the serodiagnosis of Strongyloides stercoralis infection
(Diagnostic Microbiology and Infectious Disease, 2013)
An effective and simplified DO-stat control strategy for production of rabies glycoprotein in Pichia pastoris
(Academic Press Inc Elsevier Science, 2017-04)
The glycoprotein (G-protein) of rabies virus is responsible for viral attachment to the host cell surface and induces virus neutralization antibodies. In the present study, the G-protein gene of rabies virus CVS strain was ...
The UDP-glucose: glycoprotein glucosyltransferase (UGGT), a key enzyme in ER quality control, plays a significant role in plant growth as well as biotic and abiotic stress in Arabidopsis thaliana
(2015)
Background: UDP-glucose: glycoprotein glucosyltransferase (UGGT) is a key player in the quality control mechanism (ER-QC) that newly synthesized glycoproteins undergo in the ER. It has been shown that the UGGT Arabidopsis ...
Binding of modulators to mouse and human multidrug resistance P-glycoprotein. A computational study
(Elsevier Science Inc, 2013-09)
The human multidrug resistance (MDR) P-glycoprotein (P-gp) mediates the extrusion of chemotherapeutic drugs from cancer cells. Modulators are relevant pharmaceutical targets since they are intended to control or to inhibit ...
Cattle nematodes resistant to macrocyclic lactones: Comparative effects of P-glycoprotein modulation on the efficacy and disposition kinetics of ivermectin and moxidectin
(Academic Press Inc Elsevier Science, 2010-06)
The role of the drug efflux pump, known as P-glycoprotein, in the pharmacokinetic disposition (host) and resistance mechanisms (target parasites) of the macrocyclic lactone (ML) antiparasitic compounds has been demonstrated. ...