Buscar
Mostrando ítems 81-90 de 424
A decision process for drug discovery in retinoblastoma
(Springer, 2020-11)
Intraocular retinoblastoma treatment has changed radically over the last decade, leading to a notable improvement in ocular survival. However, eyes that relapse remain difficult to treat, as few alternative active drugs ...
A decision process for drug discovery in retinoblastoma
(Springer, 2020-11)
Intraocular retinoblastoma treatment has changed radically over the last decade, leading to a notable improvement in ocular survival. However, eyes that relapse remain difficult to treat, as few alternative active drugs ...
Short linear motif core and flanking regions modulate retinoblastoma protein binding affinity and specificity
(Oxford University Press, 2018-03)
Pocket proteins retinoblastoma (pRb), p107 and p130 are negative regulators of cellular proliferation and multifunctional proteins regulating development, differentiation and chromatin structure. The retinoblastoma protein ...
Association of cone-rod homeobox transcription factor messenger RNA with pediatric metastatic retinoblastoma
(American Medical Association, 2015-07)
IMPORTANCE: Disseminated retinoblastoma is usually fatal. Identification of small amounts (minimal dissemination [MD]) of tumor cells in extraocular sites might be a tool for designing appropriate treatments. OBJECTIVE: ...
Importancia de los estudios de biología molecular en el asesoramiento genético de familias argentinas con retinoblastomaThe relevance of molecular biology studies in the genetic counselling of argentine retinoblastoma families
(Sociedad Española de Oftalmología, 2009-12)
Objetivo: Evaluar la importancia de la detección de mutaciones del gen RB1 en el asesoramiento genético de las familias argentinas con retinoblastoma. Métodos: Se incluyeron en este estudio 34 familias argentinas con ...
Prevalencia de retrinoblastoma en pacientes del Hospital Dr. Elías Santana, Santo Domingo, Rep. Dominicana, marzo 2001-Marzo 2003
(2005-12)
El retinoblastoma es una neoplasia intraocular maligna, primaria, que se origina en los retinoblatos inmaduros. Es el tumor maligno intraocular más común en la infancia, con una incidencia de 1 en 15,000 niños. El gen ...
Caracterizacion epidemiológica y evolución de los pacientes con el diagnóstico de retinoblastoma en el Servicio de Oftalmologia del Hospital Nacional de Niños ¨Dr Carlos Saenz Herrera¨ durante el periodo comprendido entre junio 2005 y junio 2018
(2019)
OBJETIVO GENERAL : Describir las características epidemiológicas y la evolución de los pacientes con el diagnostico de Retinoblastoma en el Servicio de Oftalmología del Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera” ...
TREATMENT OF EXTRAOCULAR RETINOBLASTOMA IN BRAZIL
(Harwood Acad Publ Gmbh, Taylor & Francis Group, 1995-01-01)
Between January 1986 and December 1990, 120 patients with retinoblastoma were admitted at A. C. Camargo Hospital. Among these, 32 (26.6%) were extraocular, (24 unilateral and 8 bilateral). The hereditary type was present ...
Kinetic recognition of the retinoblastoma tumor suppressor by a specific protein target
(Elsevier, 2011-09)
The retinoblastoma tumor suppressor (Rb) plays a key role in cell cycle control and is linked to various types of human cancer. Rb binds to the LxCxE motif, present in a number of cellular and viral proteins such as AdE1A, ...