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Membrane binding, endocytic trafficking and intracellular fate of high-affinity antibodies to gangliosides GD1a and GM1
(Elsevier Science, 2017-01)
Gangliosides are glycolipids embedded in the outer leaflets of the plasma membrane. Antibodies against GM1 and GD1a gangliosides are associated with selective dysfunction of motor axons in peripheral neuropathies, and ...
Ureide permease 5 (AtUPS5) connects cell compartments involved in UREIDE metabolism
(American Society of Plant Biologist, 2019-12)
Allantoin is a purine oxidative product involved in long distance transport of organic nitrogen in nodulating legumes and was recently shown to play a role in stress tolerance in other plants. The subcellular localization ...
Novel membrane-bound eIF2 alpha kinase in the flagellar pocket of Trypanosoma brucei
(Amer Soc Microbiology, 2007-11-01)
Translational control mediated by phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 (eIF2 alpha) is central to stress-induced programs of gene expression. Trypanosomatids, important human pathogens, ...
KLHL1 Controls CaV3.2 Expression in DRG Neurons and Mechanical Sensitivity to Pain
(Frontiers Media, 2020-01)
Dorsal root ganglion (DRG) neurons process pain signaling through specialized nociceptors located in their peripheral endings. It has long been established low voltage-activated (LVA) CaV3.2 calcium channels control neuronal ...
Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action
(Elsevier Science London, 2017-06)
Glucose transport is rate limiting for dietary glucose utilization by muscle and fat. The glucose transporter GLUT4 is dynamically sorted and retained intracellularly and redistributes to the plasma membrane (PM) by ...
Estudio de la relación funcional entre el tráfico intracelular de LRP1 y la respuesta celular a la insulina
(2019-03-18)
El LRP1 (low density lipoprotein receptor-related protein 1) es un receptor que se encuentra expresado en diferentes tipos celulares tales como células gliales de Müller y cardiomiocitos. Entre las diversas funciones de ...