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Identification of Potential Visceral Pain Biomarkers in Colon Exudates from Mice with Experimental Colitis: An Exploratory In Vitro Study
Chronic visceral pain (CVP) is extremely difficult to diagnose, and available analgesic treatment options are quite limited. Identifying the proteins secreted from the colonic nociceptors, or their neighbor cells within ...
IL-17 is not essential for prostate inflammation and chronic pelvic pain development in an experimental model of chronic prostatitis/chronic pelvic pain syndrome
(Elsevier Science, 2015-11)
Pain and inflammation in the absence of infection are hallmarks in Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) patients. The etiology of CP/CPPS is unclear and autoimmunity has been proposed as a cause. ...
Understanding Pain and Quality of Life for Patients With Chronic Venous Ulcers
(H M P COMMUNICATIONS, 2008)
Aim. To identify the impact of pain on quality of life (QOL) of patients with chronic venous ulcers. Methods. A cross-sectional study was performed on 40 outpatients with chronic venous ulcers who were recruited at one ...
Effects of manual therapy on fear avoidance, kinesiophobia and pain catastrophizing in individuals with chronic musculoskeletal pain: Systematic review and meta-analysis
(2021-02-01)
Objective: To systematically review the effectiveness of manual therapy on fear-avoidance, kinesiophobia, and pain catastrophizing in patients with chronic musculoskeletal pain. Literature search: Databases (Medline, EMBASE, ...
Empathy for Pain: Insula Inactivation and Systemic Treatment With Midazolam Reverses the Hyperalgesia Induced by Cohabitation With a Pair in Chronic Pain Condition
(Frontiers Media Sa, 2018-11-16)
Empathy for pain is the ability to perceive and understand the pain in the other individual. Recent studies suggested that rodents have this social ability. GABAergic system has receptors in the brain structures involved ...
Conditional TNF-alpha Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis
(International & American Associations for Dental Research, 2016)
Tumor necrosis factor-alpha(TNF-alpha) is a proalgesic cytokine that is commonly expressed following tissue injury. TNF-alpha expression not only promotes inflammation but can also lead to pain hypersensitivity in nociceptors. ...
Pannexin 1: A novel participant in neuropathic pain signaling in the rat spinal cord
(Elsevier B.V., 2014)
© 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.Pannexin 1 (panx1) is a large-pore membrane channel expressed in many tissues of mammals, including neurons and glial ...
Distinct Gender-related Sleep Pattern in an Acute Model of TMJ Pain
(Sage Publications Inc, 2009-05-01)
Since it is recognized that acute inflammation of the temporomandibular joint results in sleep disturbances in male rats, and that the orofacial region may display a site-specific effect of ovarian hormones on nociception, ...
Anti-nociceptive effects of Carpolobia lutea G. Don (Polygalaceae) leaf fractions in animal models
(2011-08-01)
Leaves from Carpolobia lutea (Polygalaceae) were screened to establish the antiulcer ethnomedicinal claim and to quantitatively isolate, elucidate the active compounds by semi-preparative HPLC. The anti-nociceptive effects ...