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Mostrando ítems 81-90 de 249
Envolvimento do receptor TRPA1 na nocicepção e neuroinflamação observada em modelos de esclerose múltipla em camundongos
(Universidade Federal de Santa MariaBrasilFarmacologiaUFSMPrograma de Pós-Graduação em FarmacologiaCentro de Ciências da Saúde, 2022-05-03)
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), and neuropathic pain and headache are significant sensory alterations that are difficult to manage in these patients. In the different ...
The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish
(Nature Publishing Group, 2019)
The Reprimo gene family comprises a group of single-exon genes for which their physiological function remains poorly understood. Heretofore, mammalian Reprimo (RPRM) has been described as a putative p53-dependent tumor ...
Decreased cruzipain and gp85/trans-sialidase family protein expression contributes to loss of Trypanosoma cruzi trypomastigote virulence
(2017)
Two cell lines derived from a single Trypanosoma cruzi clone by long-term passaging generated a highly virulent (C8C3hvir) and a low virulent (C8C3lvir) cell line. The C8C3hvir cell line was highly infective and lethal to ...
Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Aβ oligomers
(2008)
The activation of the canonical Wnt signaling pathway protects hippocampal neurons against the toxicity of Alzheimer's amyloid-β-peptide (Aβ), however, the role played by the Wnt receptors Frizzleds, has not been studied. ...
Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats
(Endocrine Soc, 2003-11-01)
Short-term cold exposure of homeothermic animals leads to higher thermogenesis and food consumption accompanied by weight loss. An analysis of cDNA-macroarray was employed to identify candidate mRNA species that encode ...
Leishmania amazonensis: Partial purification and study of the biochemical properties of the telomerase reverse transcriptase activity from promastigote-stage
(Academic Press Inc. Elsevier B.V., 2011-01-01)
Telomeres are protein-DNA complexes that protect chromosome ends from degradation and fusion. In Leishmania spp., telomeric DNA comprises a conserved TTAGGG repeat and is maintained by telomerase. Telomerase is a multisubunit ...
Leishmania amazonensis: Partial purification and study of the biochemical properties of the telomerase reverse transcriptase activity from promastigote-stage
(Academic Press Inc. Elsevier B.V., 2011-01-01)
Telomeres are protein-DNA complexes that protect chromosome ends from degradation and fusion. In Leishmania spp., telomeric DNA comprises a conserved TTAGGG repeat and is maintained by telomerase. Telomerase is a multisubunit ...