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Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos
(2011)
Abstract Background: Several mechanisms have been proposed to contribute to cardiac dysfunction in obesity models, such as alterations in calcium (Ca2+) handling proteins and β-adrenergic receptors. Nevertheless, the role ...
Gln27→Gluβ2-adrenergic receptor polymorphism in heart failure patients: Differential clinical and oxidative response to carvedilol
(2009)
We investigated the clinical response of chronic heart failure patients with β2-adrenergic receptor Gln27→Glu polymorphism treated for 6 months with carvedilol, a α/β-antagonist with antioxidant properties. The 6-min. walk ...
Response of the periodontal tissues to β-adrenergic stimulation
(elsevier, 2021-09-15)
Aims: Stimulation of β-adrenergic receptors (βAR) in osteoblasts by isoproterenol (ISO) was shown to induce Vascular Endothelial Growth Factor (VEGF) and angiogenesis in long bones. We thus aimed to determine the vascular ...
β-adrenergic receptors in the up-regulation of COX2 expression and prostaglandin production in testicular macrophages: Possible relevance to male idiopathic infertility
(Elsevier Ireland, 2019-12)
Catecholaminergic neuronal elements (CNE) and macrophages (MACs) are increased in testes of patients withidiopathic infertility. Now, we describe an anatomical proximity between CNE and MACs, expression of specificα- and ...
Efectos de la noradrenalina sobre la complejidad dendrítica en cultivos de neuronas hipocampales
(Universidad de Chile, 2012)
La neurotransmisión noradrenérgica está relacionada con procesos como el
aprendizaje y la memoria. Se ha observado en el cuadro depresivo una disminución en
la neurotransmisión de noradrenalina (NA), alteraciones de la ...
2D-QSAR and 3D-QSAR/CoMSIA studies on a series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-phenylethan-1-ol with human β3-adrenergic activity
(2017-03)
The β3 adrenergic receptor is raising as an important drug target for the treatment of pathologies such as diabetes, obesity, depression, and cardiac diseases among others. Several attempts to obtain selective and high ...
Lack of Gαi2 leads to dilative cardiomyopathy and increased mortality in β1-adrenoceptor overexpressing mice
(Oxford University Press, 2015-12)
Aims Inhibitory G (Gi) proteins have been proposed to be cardioprotective. We investigated effects of Gαi2 knockout on cardiac function and survival in a murine heart failure model of cardiac β1-adrenoceptor overexpression. ...