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Expressão heteróloga, purificação e análise da imunoreatividade do alérgeno antígeno 5 do veneno de Polybia paulista (Hymenoptera, Vespidae)
(Universidade Estadual Paulista (Unesp), 2017-02-23)
A vespa social Polybia paulista é muito agressiva e abundante nos Estados de São Paulo e Sul de Minas Gerais e, responsável por muitos acidentes de importância médica. Os principais alérgenos (Fosfolipase, Hialuronidase e ...
Peptídeos sintéticos no estudo do sistema toxina-antitoxina ParE/ParD
(Universidade Estadual Paulista (Unesp), 2017-06-27)
O sistema ParE-ParD é um sistema Toxina-Antitoxina (TA) do tipo II (composto por duas proteínas) encontrado no plasmídeo RK2 de uma gama de bactérias. A antitoxina ParD (9kDa) é capaz de neutralizar a citotoxicidade da ...
Immunisation of cattle against Babesia bovis combining a multi-epitope modified vaccinia Ankara virus and a recombinant protein induce strong Th1 cell responses but fails to trigger neutralising antibodies required for protection
(Elsevier, 2019-10)
Protection against the intraerythrocytic protozoan parasite Babesia bovis depends on both strong innate and adaptive immune response, this latter involving the presentation of parasite antigens to CD4+ T-lymphocytes by ...
Bacterially produced metabolites protect C. elegans neurons from degeneration
(Public Library of Science, 2020)
Caenorhabditis elegans and its cognate bacterial diet comprise a reliable, widespread model to study diet and microbiota effects on host physiology. Nonetheless, how diet influences the rate at which neurons die remains ...
Fragmentos de KCTD5 como inhibidores de la proliferación y migración celular en modelo de melanoma
(Universidad de Chile, 2020)
Las proteínas son macromoléculas esenciales para el funcionamiento celular y condiciones que alteren su vida media, pueden causar diversas enfermedades. Algunos miembros de la familia KCTD (Potassium channel tetramerization ...
Bacterially produced metabolites protect C. elegans neurons from degeneration
(Public Library Science, 2020)
Caenorhabditis elegans and its cognate bacterial diet comprise a reliable, widespread model to study diet and microbiota effects on host physiology. Nonetheless, how diet influences the rate at which neurons die remains ...
Bacterially produced metabolites protect C. elegans neurons from degeneration
(Public Library Science, 2020)
Caenorhabditis elegans and its cognate bacterial diet comprise a reliable, widespread model to study diet and microbiota effects on host physiology. Nonetheless, how diet influences the rate at which neurons die remains ...
Two novel dermonecrotic toxins LiRecDT4 and LiRecDT5 from Brown spider (Loxosceles intermedia) venom: From cloning to functional characterization
(Elsevier B.V., 2007-03-01)
Loxoscelism (the condition produced by the bite of brown spiders) has been reported worldwide, but especially in warmer regions. Clinical manifestations include skin necrosis with gravitational spreading while systemic ...
Interação de proteínas Vip3A e Cry1la10 de Bacillus thuringiensis com atividade inseticida a lepidópteros-praga
(Universidade Estadual Paulista (Unesp), 2015-02-06)
Vip3Aa and Cry1Ia proteins have potential in control of Lepidopteran pest and emerge as a promising alternative in the pest resistance management the Cry1A proteins, which has been highly used in the formulation of commercial ...
Shaping mechanisms of metal specificity in a family of metazoan metallothioneins: evolutionary differentiation of mollusc metallothioneins
(Biomed Central, 2011-01)
Background: The degree of metal binding specificity in metalloproteins such as metallothioneins (MTs) can be crucial for their functional accuracy. Unlike most other animal species, pulmonate molluscs possess homometallic ...