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Assessment of In vitro cytotoxicity of imidazole ionic liquids and inclusion in targeted drug carriers containing violacein
(Royal Society of Chemistry, 2020-08-10)
Violacein (Viol) is a pigment produced by several Gram-negative bacteria with many bioactivities, such as anticancer, virucide, and antiparasitic. However, violacein is insoluble under physiological conditions preventing ...
Anti-herpetic activity of a sulfated xylomannan from Scinaia hatei
(Pergamon-Elsevier Science Ltd, 2008-08)
Many viruses display affinity for cell surface heparan sulfate proteoglycans with biological relevance in virus entry. This raises the possibility of the application of sulfated polysaccharides in antiviral therapy. In ...
A synthetic stigmastane displays antiadenoviral activity and reduces the inflammatory response to viral infection
(Elsevier Science, 2020-09)
Although human adenovirus (ADV) infections are mild and self-limited in immunocompetent individuals, they can be severe and life-threatening in immunocompromised patients. Despite their significant clinical impact, there ...
Antiretroviral Activity of fucoidans extracted from the Brown Seaweed Adenocystis utricularis
(John Wiley & Sons Ltd, 2009-05)
Treatment of human immunodeficiency virus type 1 (HIV-1, causative agent of AIDS) infection represents a major challenge in antiviral therapeutics. Many difficulties are associated with the treatment, including toxicity, ...
β-Carboline derivatives as novel antivirals for herpes simplex virus
(Elsevier Science, 2018-10)
Several commercial and novel synthetic β-carbolines (βCs) were evaluated for their antiviral activity against herpes simplex virus type 1 (HSV-1) using an adapted MTS assay. Of 21 drugs tested, although 11 exerted antiviral ...
Structure and antiviral activity of sulfated fucans from Stoechospermum marginatum
(Pergamon-Elsevier Science Ltd, 2006-11)
A sulfated fucan containing fraction (SmWE) was isolated from water extract of the brown seaweed Stoechospermum marginatum collected from the Arabian Sea. Anion exchange chromatography of the crude fraction results in the ...
Inhibitory effect of sulfated galactans from the marine alga Bostrychia montagnei on herpes simplex virus replication in vitro
(Elsevier Gmbh, 2001-02)
Sulfated polysaccharides exhibit many biological properties such as antiviral and anticoagulant activities. Herein, we report the antiviral activity of sulfated galactans extracted from the red sea-weed Bostrychia montagnei ...
Therapeutic potential of ibuprofen inhalation for COVID-19 pneumonia: Report of two first cases
(Journal of Clinical Images and Medical Case Reports, 2021-10)
No specific and effective antiviral treatment has been approved for COVID-19 so far. Systemic corticosteroid and remdesivir have shown to decrease mortality in COVID-19 patients, but mortality still is elevated. We propose ...
Mode of inactivation of arenaviruses by disulfide-based compounds
(Elsevier Science, 2002-12)
Several disulfide-based compounds, including intermolecular aromatic disulfides of the type Ph-S-S-Ph and dithianes with the sulfur atoms tethered in a ring structure, have shown effective inhibitory activity against the ...
Avaliação dos Pontos Quânticos de Óxido de Zinco (PQs ZnO) na mortalidade de imaturos de Aedes aegypti (Diptera: Culicidae)
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM BIOLOGIA PARASITÁRIA, 2018-03-26)
The specie Aedes aegypti is the greatest medical importance in Brazil, can transmit
the dengue virus, urban yellow fever, zika, chinkungunya and others arboviruses.
Insecticides still appear as an important tool in ...