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Dimorfismo sexual en el efecto de glucocorticoides sobre el patrón de expresión de microRNAs en el hipocampo de roedores
(Universidad de Chile, 2019)
Los glucocorticoides son hormonas esteroidales secretadas por las glándulas suprarrenales en un proceso dependiente de la actividad circadiana del eje hipotálamo-hipófisis-adrenal (HHA) o de un estímulo exógeno. Se sabe ...
Deletion of hippocampal glucocorticoid receptors unveils sex-biased microRNA expression and neuronal morphology alterations in mice
(Elsevier, 2021)
Sex differences in the brain have prompted many researchers to investigate the underlying molecular actors, such as the glucocorticoid receptor (GR). This nuclear receptor controls gene expression, including microRNAs ...
Evidence for glucocorticoid receptor transport on microtubules by dynein
(American Society for Biochemistry and Molecular Biology, 2004)
Rapid, ligand-dependent movement of glucocorticoid receptors (GR) from cytoplasm to the nucleus is hsp90-dependent, and much of the movement system has been defined. GR.hsp90 heterocomplexes isolated from cells contain one ...
Urinary free cortisol is not a biochemical marker of hypertension
(OXFORD UNIV PRESS, 2007)
Background: Increasing evidence suggests that glucocorticoids might play a role in blood pressure (BP) control. These reports show that cortisol (F) can increase the BP acting on the mineralocorticoid receptor in kidney, ...
Treadmill slope modulates inflammation, fiber type composition, androgen, and glucocorticoid receptors in the skeletal muscle of overtrained mice
(2017-10-25)
Overtraining (OT) may be defined as an imbalance between excessive training and adequate recovery period. Recently, a downhill running-based overtraining (OTR/down) protocol induced the nonfunctional overreaching state, ...
Nuclear Import of the Glucocorticoid Receptor-hsp90 Complex through the Nuclear Pore Complex Is Mediated by Its Interaction with Nup62 and Importin β
(American Society for Microbiology, 2009-09)
Glucocorticoid receptor (GR) is cytoplasmic in the absence of ligand and localizes to the nucleus after steroid binding. Previous evidence demonstrated that the hsp90-based heterocomplex bound to GR is required for the ...
Depressão: aspectos fisiopatológicos e o efeito tipo-antidepressivo da apocinina
(Universidade Federal de Santa MariaBrasilFarmacologiaUFSMPrograma de Pós-Graduação em FarmacologiaCentro de Ciências da Saúde, 2020-02-17)
Depression is considered a public health challenge around the world. According to the World Health Organization, more than 300 million people (approximately 6% of the world population) are affected by this disorder. ...
Regulation of corticosterone function during early weaning and effects on gastric cell proliferation
(ElsevierBurbank, 2014-03)
Objectives: The development of the gastrointestinal tract depends on many elements, including glucocorticoids. In the current study, we evaluated the effects of early weaning on corticosterone function and the growth of ...
Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice
(Blackwell Scientific Publications, 2013)