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Venlafaxine-induced damage to seminiferous epithelium, spermiation, and sperm parameters in rats: A correlation with high estrogen levels
(2020-01-01)
Background: Venlafaxine (selective serotonin and norepinephrine reuptake inhibitor) use has increased worldwide. However, the impact of venlafaxine on testes and sperm parameters has not been investigated. Objectives: We ...
In vitro toxicological assessment of Arrabidaea brachypoda (DC.) Bureau: Mutagenicity and estrogenicity studies
(2017-11-01)
Arrabidaea brachypoda (DC.) Bureau is a shrub native Cerrado, known as “cipó-una”, “tintureiro” or “cervejinha do campo” and popularly used in Southeastern and Northeastern Brazil to treatment of kidney stones and painful ...
Nuclear role for human Argonaute-1 as an estrogen-dependent transcription coactivator
(Rockefeller University Press, 2020-09)
In mammals, argonaute (AGO) proteins have been characterized for their roles in small RNA mediated posttranscriptional and also in transcriptional gene silencing. Here, we report a different role for AGO1 in estradiol-triggered ...
Estradiol, acting through ERα, induces endothelial non-classic renin-angiotensin system increasing angiotensin 1-7 production.
(Elsevier Ireland, 2016-02)
Intracellular renin-angiotensin system (RAS) can operate independently of the circulating RAS. Estrogens provide protective effects by modulating the RAS. Our aim was to investigate the effect of estradiol (E2) on angiotensin ...
Biological activity of genistein and soy extracts: Selective induction of some but not all estrogenic responses in the prepubertal rat uterus Actividad biológica de Genisteína y extractos de soya: Inducción selectiva de algunas pero no todas las respuesta
(2010)
The existence of multiple kinds of estrogen receptors (ERs), involved in independent groups of responses, allows their dissociation and opens the possibility to selectively induce beneficial responses but not those considered ...
Astrocytes mediate protective actions of estrogenic compounds after traumatic brain injury
(2019-02-01)
Traumatic brain injury (TBI) is a serious public health problem. It may result in severe neurological disabilities and in a variety of cellular metabolic alterations for which available therapeutic strategies are limited. ...
The importance of estrogen for bone protection in experimental hyperthyroidism in human osteoblasts
(2019-08-15)
Triiodothyronine (T3) and estrogen (E2) play important roles in the bone remodeling process and signaling of receptor activator of the nuclear factor-kappa β (RANKL) and osteoprotegerin (OPG) expressed by osteoblasts. ...
Zearalenone, an estrogenic mycotoxin, is an immunotoxic compound
(Basel, 2014-03)
The aim of this study was to assess the toxic effects of zearalenone (ZEA) on the immune function. Ovariectomised rats were treated daily by gavage with 3.0 mg/kg of ZEA for 28 days. Body weight gain, food consumption, ...
Aryl hydrocarbon receptor activation leads to impairment of estrogen-driven chicken vitellogenin promoter activity in LMH cells
(Elsevier Science Inc., 2013-03)
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates most of the toxic effects of environmental contaminants. Among the multiple pleiotropic responses elicited by AHR agonists, the ...
Higher estrogen levels during pregnancy in Andean than European residents of higy altitude suggest differences in aromatase activity
(J Clin Endocrinol Metab, 2014-08)
Context: Uteroplacental hypoxia has been reported to lower estrogen levels in preeclampsia as the
result of reduced aromatase activity.
Objective: We asked whether the chronic hypoxia of residence at high altitude in the ...