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Suramin inhibits macrophage activation by human group IIA phospholipase A(2), but does not affect bactericidal activity of the enzyme
(BIRKHAUSER VERLAG AG, 2009)
Suramin is a polysulphonated napthylurea antiprotozoal and anthelminitic drug, which also presents inhibitory activity against a broad range of enzymes. Here we evaluate the effect of suramin on the hydrolytic and biological ...
A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases
(Nature Publishing Group, 2017-12)
Carbapenem-resistant Enterobacteriaceae threaten human health, since carbapenems are last resort drugs for infections by such organisms. Metallo-β-lactamases (MβLs) are the main mechanism of resistance against carbapenems. ...
ATP-binding cassette exporters: Structure and mechanism with a focus on P-glycoprotein and MRP1
(Bentham Science Publishers, 2019-09)
Background: Proteins that belong to the ATP-binding cassette superfamily include transporters that mediate the efflux of substrates from cells. Among these exporters, P-glycoprotein and MRP1 are involved in cancer multidrug ...
Development of organic-inorganic polymeric film formers for controlled drug release and wound care
(Univ Fed Rio De Janeiro, Lab Hidrogenio, 2014-01-01)
Film forming polymeric systems represents a new and unexplored technology of systems forskin or wounds protection and for controlled drug release. The aim of this work was to study the use of polymeric organic-inorganic ...
Novel enzyme-polymer conjugates for biotechnological applications
(PeerJ, 2013-01)
In the present research, a rapid, simple and efficient chemoselective method for the site-directed incorporation of tailor-made polymers into protein to create biocatalysts with excellent properties for pharmaceutical ...
In silico-guided drug repurposing: identification of non-competitive inhibitors of Trypanosoma cruzi and Plasmodium falciparum cysteine proteases
(Fundación Revista Medicina, 2020)
Abstract/Resumen: Trypanosoma cruzi and Plasmodium falciparum are the etiologic agents of Chagas disease and Malaria, respectively. Cysteine proteases play key roles in the pathogenesis and survival of these parasites, ...
Nucleotidases e depressão: efeito de fármacos antidepressivos no catabolismo do ATP extracelular
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2007)
Depression is the most common manifestation of affective disorders. It is one of the most disable diseases, and causes a significant burden to both the individual and the society and, if not treated, it can increase morbidity ...
Nucleotidases e depressão: efeito de fármacos antidepressivos no catabolismo do ATP extracelular
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2007)
Depression is the most common manifestation of affective disorders. It is one of the most disable diseases, and causes a significant burden to both the individual and the society and, if not treated, it can increase morbidity ...
Participação do sistema endocanabinoide em modelos animais de efeitos adversos motores induzidos pelo haloperidol
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Ciências Biológicas - Fisiologia e FarmacologiaUFMG, 2017-07-11)
Schizophrenia is a psychiatric disorder in which symptoms are disconnection with reality, mood and cognition alterations. The main treatment consists in antipsychotic drugs, which mainly act as dopamine D2 receptor ...