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Comparative study of the neural differentiation capacity of mesenchymal stromal cells from different tissue sources: An approach for their use in neural regeneration therapies
(Public Library of Science, 2019)
Mesenchymal stem cells (MSCs) can trans/differentiate to neural precursors and/or mature neurons and promote neuroprotection and neurogenesis. The above could greatly benefit neurodegenerative disorders as well as in the ...
Avaliação da citotoxicidade do fármaco Triclosan na transdiferenciação de células estreladas hepáticas LX-2 e seu potencial indutor tumoral
(Universidade Estadual Paulista (Unesp), 2018-12-11)
To evaluate the potential of the triclosan drug (TCS) for its safe use in the process of reversion of the hepatic fibrosing, new research on becomes relevant. TCS is characterized as being an antimicrobial agent used in a ...
Transcriptomic Analysis of Mouse Cochlear Supporting Cell Maturation Reveals Large-Scale Changes in Notch Responsiveness Prior to the Onset of Hearing
(2016)
Neonatal mouse cochlear supporting cells have a limited ability to divide and trans-differentiate into hair cells, but this ability declines rapidly in the two weeks after birth. This decline is concomitant with the ...
Consequências da restrição proteica na vida intrauterina e na lactação sobre as adaptações na morfologia de ilhotas pancreáticas durante a prenhez
(Universidade Federal de Mato GrossoBrasilFaculdade de Nutrição (FANUT)UFMT CUC - CuiabáPrograma de Pós-Graduação em Nutrição, Alimentos e Metabolismo, 2017-08-03)
The population of pancreatic -cells is dynamic and susceptible to compensatory
changes to maintenance of glucose levels within a narrow range. The -cells mass
adapts under various pathological and physiological conditions. ...
O potencial das células intestinais como fonte de células progenitoras pancreáticas
(Universidade Federal de Santa MariaBRMedicina VeterináriaUFSMPrograma de Pós-Graduação em Medicina Veterinária, 2012-02-24)
The objective of the present study was to establish a primary culture of intestinal cells
and to characterize the mRNA expression profile of genes related to pancreatic formation,
development and insulin metabolism. The ...
Premature senescence of T-cells favors bone loss during osteolytic diseases. A new concern in the osteoimmunology arena
(International Society on Aging and Disease, USA, 2021)
Cellular senescence is a biological process triggered in response to time-accumulated DNA damage, which prioritizes cell survival over cell function. Particularly, senescent T lymphocytes can be generated prematurely during ...
Genetic ablation of pannexin1 counteracts liver fibrosis in a chemical, but not in a surgical mouse model
(2018-08-01)
Liver fibrosis is the final common pathway for almost all causes of chronic liver injury. This chronic disease is characterized by excessive deposition of extracellular matrix components mainly due to transdifferentiation ...
Hepatogenic and neurogenic differentiation of bone marrow mesenchymal stem cells from abattoir-derived bovine fetuses
(BIOMED, 2014-07-10)
Background: Mesenchymal stem cells (MSC) are multipotent progenitor cells characterized by their ability to both
self-renew and differentiate into tissues of mesodermal origin. The plasticity or transdifferentiation ...
Undifferentiated Pulmonary Adenocarcinoma of Clear Cells Associated to Hypertrophic Osteopathy in a Dog
(Univ Fed Rio Grande Do Sul, 2014-01-01)
Background: Most of the primary pulmonary tumors in dogs are malignant and from epithelial origin, being bronchioalveolar tumors more prevalent. Adenocarcinoma of clear cells, however, is a very rare pulmonary tumor and ...
Undifferentiated pulmonary adenocarcinoma of clear cells associated to hypertrophic osteopathy in a dog
(2014-01-01)
Background: Most of the primary pulmonary tumors in dogs are malignant and from epithelial origin, being bronchioalveolar tumors more prevalent. Adenocarcinoma of clear cells, however, is a very rare pulmonary tumor and ...