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ApoER2 expression increases AB production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of Y-secretase activity
(2007)
Abstract
Background
The generation of the amyloid-β peptide (Aβ) through the proteolytic processing of the amyloid precursor protein (APP) is a central event in the pathogenesis ...
Rol de las especies reactivas de oxígeno en la modificación de la red mitocondrial y en la disminución de la expresión de la isoforma 2 del receptor de ryanodina inducidos por los oligómeros del péptido Aβ en neuronas
(Universidad de Chile, 2015)
La enfermedad de Alzheimer (EA) es un desorden neurodegenerativo caracterizado por la pérdida progresiva de memoria. Los oligómeros solubles sinaptotóxicos del péptido β-amiloide (AβOs) son reconocidos como los agentes ...
Efeito de nanocápsulas contendo curcumina no comportamento tipo depressivo e no estresse oxidativo induzidos por β-amilóide em camundongosEffect of nanocappsules containing curcumin on depressive type behavior and oxidative stress induced by β-amyloid in mice
(Universidade Federal do PampaUNIPAMPAMestrado Acadêmico em BioquímicaBrasilCampus Uruguaiana, 2021)
Modulação do sistema das poliaminas e bloqueio seletivo de correntes de K+ do tipo A reverte o dano cognitivo induzido por peptídeo β-amiloide25-35
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2013-11-18)
In Alzheimer s disease (AD), β-amyloid peptide (Aβ) has been linked with synaptic loss and cognitive dysfunction, albeit the precise mechanism remains unknown. An involvement of N-Methyl-D-Aspartate receptors (NMDAR) in ...
Unraveling the Burden of Iron in Neurodegeneration: Intersections with Amyloid Beta Peptide Pathology
(Hindawi Publishing Corporation, 2018-01-31)
Iron overload is a hallmark of many neurodegenerative processes such as Alzheimer's, Parkinson's, and Huntington's diseases. Unbound iron accumulated as a consequence of brain aging is highly reactive with water and oxygen ...
Imunossensor para o diagnóstico da Doença de Alzheimer através da detecção do autoanticorpo Anti-βA42
(Universidade Federal de São Paulo (UNIFESP), 2020-02-28)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease, responsible for the most case of dementia. This work offers a promising solution that seeks the early disease diagnosis through the immunosensor development ...
RyR2-mediated Ca2+ release and mitochondrial ROS generation partake in the synaptic dysfunction caused by amyloid β peptide oligomers
(Frontiers Research Foundation, 2017)
© 2017 SanMartín, Veloso, Adasme, Lobos, Bruna, Galaz, García, Hartel, Hidalgo and Paula-Lima. Amyloid β peptide oligomers (AβOs), toxic aggregates with pivotal roles in Alzheimer’s disease, trigger persistent and low ...
Vitamin d increases aβ140 plasma levels and protects lymphocytes from oxidative death in mild cognitive impairment patients
(Bentham Science Publishers B.V., 2018)
© 2018 Bentham Science Publishers.Background: Mild cognitive impairment (MCI) has an increased rate of progression to dementia. Alterations of some metabolic factors, such as deficiency of vitamin D, are a risk factor for ...
Role of Glial Hemichannels in Neurodegenerative Processes: Application to Alzheimer´S Disease
(2010)
Alzheimer’s disease (AD) is an age-related, neurodegenerative disease that results in memory loss, behavior and personality changes, as well as a decrease in
thinking abilities. Among tissue manifestations is included the ...