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The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases?
(Elsevier Science, 2016-10-15)
One of the salient features of most neurodegenerative diseases is the aggregation of specific proteins in the brain. This proteostasis imbalance is proposed as a key event triggering the neurodegenerative cascade. The ...
XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy
(Taylor and Francis Inc., 2009)
Endoplasmic reticulum (ER) stress has been extensively described in many protein misfolding disorders including amyotrophic lateral sclerosis (ALS). Adaptation to ER stress is mediated by the activation of an integrated ...
ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders
(Elsevier, 2015)
Alzheimer's and Prion diseases are two neurodegenerative conditions sharing different pathophysiological characteristics. Disease symptoms are associated with the abnormal accumulation of protein aggregates, which are ...
ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders
(Elsevier, 2015)
© 2014 Elsevier B.V. Alzheimer's and Prion diseases are two neurodegenerative conditions sharing different pathophysiological characteristics. Disease symptoms are associated with the abnormal accumulation of protein ...
Avaliação da ativação de componentes da via de resposta a proteínas não dobradas (UPR) na infecção pelo Zika virus
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MICROBIOLOGIAPrograma de Pós-Graduação em MicrobiologiaUFMG, 2019-06-17)
ABSTRACT
Zika virus (ZIKV), of the genus Flavivirus, is the causative agent of an emerging infectious disease in many countries, with a high number of cases reported in recent years and a strong causal association with ...
Targeting the unfolded protein response for disease intervention
(Taylor & Francis, 2015)
Introduction: The accumulation of misfolded proteins in the endoplasmic reticulum (ER)
generates a stress condition that engages the unfolded protein response (UPR). The UPR is an
adaptive reaction that aims to reestablish ...
RHBDD2 overexpression promotes a chemoresistant and invasive phenotype to rectal cancer tumors via modulating UPR and focal adhesion genes
(Elsevier Science, 2020-08)
The current standard of care for locally advanced rectal cancer (RC) is neoadjuvant radio-chemotherapy (NRC) with 5-fluorouracil (5Fu) as the main drug, followed by surgery and adjuvant chemotherapy. While a group of ...
ER proteostasis disturbances in Parkinson's disease: Novel insights
(Frontiers Media S.A., 2015)
ER proteostasis disturbances in Parkinson's disease: novel insights
(Frontiers Research Foundation, 2015)