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Development of Magoh protein-overexpressing HEK cells for optimized therapeutic protein production
(Journal of the Serbian Chemical Society, 2020-04)
In the pharmaceutical industry, the need for high levels of protein expression in mammalian cells has prompted the search for new strategies, including technologies to obtain cells with improved mechanisms that enhance its ...
Structure-based drug design to overcome drug resistance: challenges and opportunities
(Bentham ScienceBussum, 2014-02)
Drug resistance is a common concern for the development of novel antiviral, antimicrobial and anticancer therapies. To overcome this problem, several strategies have been developed, many of which involving the theme of ...
A Comprehensive Haplotype Targeting Strategy for Allele-Specific HTT Suppression in Huntington Disease.
(Elsevier, 2019)
Huntington disease (HD) is a fatal neurodegenerative disorder caused by a gain-of-function mutation in HTT. Suppression of mutant HTT has emerged as a leading therapeutic strategy for HD, with allele-selective approaches ...
Nuevas perspectivas en el manejo de la hipertensión
(Sociedad Médica de Santiago, Chile, 2021)
Arterial hypertension is one of the biggest public health problems. The research
in this area has been relentless and productive, allowing to identify new
pathophysiological mechanisms from which new therapeutic options ...
Cholangiocyte death in ductopenic cholestatic cholangiopathies: Mechanistic basis and emerging therapeutic strategies
(Pergamon-Elsevier Science Ltd, 2019-02)
Among hepatic diseases, cholestatic ductopenic cholangiopathies are poorly studied, and they are rarely given the importance they deserve, especially considering their high incidence in clinical practice. Although cholestatic ...
Impacto del burnout del psicólogo en la relación terapéutica
(Universidad Católica de Pereira, 2019)
Organophosphorus-induced delayed neuropathy: A simple and efficient therapeutic strategy
(Elsevier B.V., 2014)
The degradation of amyloid beta as a therapeutic strategy in Alzheimer's disease and cerebrovascular amyloidoses
(Springer/Plenum Publishers, 2002-11)
The deposition of 4-kDa amyloid beta peptide in the brain is a prominent feature of several human diseases. Such process is heterogeneous in terms of causative factors, biochemical phenotype, localization and clinical ...