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Diversity in mitotic DNA repair efficiencies between commercial inbred maize lines and native Central American purple landraces
(2022-10)
Background: Homologous recombination allows plants to repair double strand breaks in DNA, which if unrepaired
may lead to cell death. In this project, we determined the relative DNA repair efciency of the US inbred lines ...
Estresse oxidativo e lesões no DNA: papel da 8-oxoguanina na viabilidade do Trypanosoma cruzi
(Universidade Federal de Minas GeraisUFMG, 2013-03-21)
The formation of DNA lesions is one of the consequences of oxidative stress, which might result in genomic instability and lead to cell death. Guanine is the base that is most susceptible to oxidation due to its low redox ...
Análise da expressão gênica em Trypanosoma cruzi em resposta à radiação ionizante pela técnica de microarranjo de DNA
(Universidade Federal de Minas GeraisUFMG, 2011-03-10)
Among the various types of damages caused by ionizing radiation, the lesions of greatest biological importance are the double-stranded DNA breaks. The tolerance for this type of damage requires an efficient apparatus for ...
Variation in DNA repair gene XRCC3 affects susceptibility to astrocytomas and glioblastomas
(FUNPEC-EDITORARIBEIRAO PRETO, 2012)
The gene XRCC3 (X-ray cross complementing group 3) has the task of repairing damage that occurs when there is recombination between homologous chromosomes. Repair of recombination between homologous chromosomes plays an ...
Molecular and functional characteristics of DNA polymerase beta-like enzymes from trypanosomatids
(Frontiers Media, 2021)
Trypanosomatids are a group of primitive unicellular eukaryotes that can cause diseases in plants, insects, animals, and humans. Kinetoplast genome integrity is key to trypanosomatid cell survival and viability. Kinetoplast ...
Estudo dos mecanismos de sinalização e reparo do dano de DNA durante o estresse replicativo em Trypanosoma cruzi
(Universidade Federal de Minas GeraisBrasilPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2019-05-22)
Unrepaired DNA damage, limited concentration of free dNTPs, or topological stress caused by DNA transcription may slow or stall the replication fork progression, which is known as replicative stress. DNA topoisomerase 3α ...
SIRT6 recruits SNF2H to sites of DNA breaks, preventing genomic instability through chromatin remodeling
(Cell Press, 2013-08)
DNA damage is linked to multiple human diseases, such as cancer, neurodegeneration, and aging. Little is known about the role of chromatin accessibility in DNA repair. Here, we find that the deacetylase sirtuin 6 (SIRT6) ...
Biophysical characterization and molecular phylogeny of human KIN protein
(Springer, 2019-10-01)
The DNA/RNA-binding KIN protein was discovered in 1989, and since then, it has been found to participate in several processes, e.g., as a transcription factor in bacteria, yeasts, and plants, in immunoglobulin isotype ...
Structural Basis of Importin-alpha-Mediated Nuclear Transport for Ku70 and Ku80
(Academic Press Ltd Elsevier B.V. Ltd, 2014)
Biochemical studies with DNA polymerase beta and DNA polymerase beta-PAK of Trypanosoma cruzi suggest the involvement of these proteins in mitochondrial DNA maintenance
(Elsevier B.V., 2008-11-01)
Mammalian DNA polymerase p is a nuclear enzyme involved in the base excision and single-stranded DNA break repair pathways. in trypanosomatids, this protein does not have a defined cellular localization, and its function ...