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Mostrando ítems 71-80 de 106
A loss-of-function homozygous mutation in DDX59 implicates a conserved DEAD-box RNA helicase in nervous system development and function
(Wiley-liss, div John Wiley & Sons Inc., 2018-02)
We report on a homozygous frameshift deletion in DDX59 (c.185del: p.Phe62fs*13) in a family presenting with orofaciodigital syndrome phenotype associated with a broad neurological involvement characterized by microcephaly, ...
Neuron’s little helper: the role of primary cilia in neurogenesis
(TaylorFrancis, 2016)
The generation of new neurons involves a great variety of cell-extrinsic and cell-intrinsic signals. The primary cilium, long regarded as an “evolutionary vestige,” has emerged as an essential signaling hub in many cells, ...
Inhibition of the 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Induces Orofacial Defects in Zebrafish
(Wiley, 2016)
Background: Orofacial clefts (OFCs) are common birth defects, which include a range of disorders with a complex etiology affecting formation of craniofacial structures. Some forms of syndromic OFCs are produced by defects ...
Um mecanismo molecular compartilhado na padronização de nadadeiras em peixes pulmonados e membros em tetrápodes
(Universidade Federal do ParáBrasilInstituto de Ciências BiológicasUFPAPrograma de Pós-Graduação em Genética e Biologia Molecular, 2019)
Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries
(2020-12-01)
Glioblastoma is a severe type of brain tumor with a poor prognosis and few therapy options. Temozolomide (TMZ) is one of these options, however, with limited success, and failure is mainly due to tumor resistance. In this ...
Elongator subunit 3 (Elp3) Is required for Zebrafish trunk development
(MDPI, 2020)
Transfer RNAs (tRNAs) are the most post-transcriptionally modified RNA species. Some of these modifications, especially the ones located in the anti-codon loop, are required for decoding capabilities of tRNAs. Such is the ...
Integrative analysis of global gene expression identifies opposite patterns of reactive astrogliosis in aged human prefrontal cortex
The prefrontal cortex (PFC) is one of the brain regions with more prominent changes in human aging. The molecular processes related to the cognitive decline and mood changes during aging are not completely understood. To ...
Determinants of differential functions of galectin-8 on T cells and tumoral cells : interplay of galectin-8 isoforms, integrin and growth factor signaling pathways.
(2014)
Galectins are a subfamily of lectins involved in a variety of cellular processes mainly related with the immune system and cancer. Galectins are secreted through unconventional mechanisms, because they lack a signal peptide, ...
Mecanismos moleculares involucrados en la diferenciación neuronal de células madre mesenquimales humanas derivadas de tejido adiposoMolecular mechanisms involved in neuronal differentiation of human adipose tissue-derived mesenchymal stem cells
(Universidad Nacional de Quilmes, 2014-04-25)
Como el sistema nervioso tiene una capacidad limitada de autorreparación, y la neurogénesis en el adulto está restringida a ciertas regiones del cerebro, existe un gran interés en la posibilidad de reparar el sistema ...