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Relación entre la estructura y la función de M6a: endocitosis y reciclado
(2019-03-27)
La glicoproteína de membrana M6a se encuentra asociada a enfermedades neuropsiquiátricas como la depresión, la esquizofrenia y fallas en el aprendizaje. Se ha descripto que contribuye positivamente en la extensión de ...
Caveolina-1 favorece la activación de rab5 promoviendo la migración y la activación del eje p85α/tiam1/rac-1 en células de cáncer metastásico y en un modelo de metástasis in vivo en ratones c57bl/6
(Universidad de Chile, 2015)
El cáncer constituye una de las principales causas de muerte en Chile y el mundo.
Particularmente, la agresividad de esta enfermedad subyace en la diseminación de las
células tumorales hacia otros tejidos, fenómeno ...
D-propranolol impairs egfr trafficking and destabilizes mutant p53 counteracting akt signaling and tumor malignancy
(2021-07-02)
Cancer therapy may be improved by the simultaneous interference of two or more onco-genic pathways contributing to tumor progression and aggressiveness, such as EGFR and p53. Tumor cells expressing gain-of-function (GOF) ...
Role of plasma-membrane-bound sialidase NEU3 in clathrin-mediated endocytosis
(Portland Press, 2015-08)
Gangliosides are sialic acid-containing glycosphingolipids mainly expressed at the outer leaflet of the plasma membrane. Sialidase NEU3 is a key enzyme in the catabolism of gangliosides with its up-regulation having been ...
Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells
(Nature Publishing Group, 2016-12)
Cross-presentation by MHC class I molecules allows the detection of exogenous antigens by CD8+ T lymphocytes. This process is crucial to initiate cytotoxic immune responses against many pathogens (i.e. Toxoplasma gondii) ...
Rab35 functions in axon elongation are regulated by P53-related protein kinase in a mechanism that involves Rab35 protein degradation and the microtubule-associated protein 1B
(Society for Neuroscience, 2016)
© 2016 the authors. Rab35 is a key protein for cargo loading in the recycling endosome. In neuronal immortalized cells, Rab35 promotes neurite differentiation. Here we describe that Rab35 favors axon elongation in rat ...