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Triptan partition in model membranes
(Springer, 2014-10)
In this work, we report a molecular dynamics simulations study of protonated triptans, sumatriptan and naratriptan, in a fully hydrated bilayer of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidyl-choline (POPC). The simulations ...
Distribution of neutral prilocaine in a phospholipid bilayer: Insights from molecular dynamics simulations
(John Wiley & Sons Inc, 2008-11-05)
In this work, we report a 20-ns constant pressure molecular dynamics simulation of prilocaine (PLC), in amine-amide local anesthetic, in a hydrated liquid crystal bilayer of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine. ...
Preferential location of prilocaine and etidocaine in phospholipid bilayers: A molecular dynamics study
(Elsevier B.V. Sa, 2009-11-01)
In this work, we report a 20-ns constant pressure molecular dynamics simulation of the uncharged form of two amino-amide local anesthetics (LA). etidocaine and prilocaine, present at 1:3 LA:lipid, molar ratio inside the ...
Distribution of neutral prilocaine in a phospholipid bilayer: Insights from molecular dynamics simulations
(John Wiley & Sons Inc, 2008-11-05)
In this work, we report a 20-ns constant pressure molecular dynamics simulation of prilocaine (PLC), in amine-amide local anesthetic, in a hydrated liquid crystal bilayer of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine. ...
Layer-by-layer films containing emodin or emodin encapsulated in liposomes for transdermal applications
(2018-02-01)
Dermal drug release systems are an important area of research because they can be applied to the skin in a non-invasive procedure using a lower concentration of drugs. In this study, we have developed two types of ...
Interactions of Lipid Polar Headgroups with Carbendazim Fungicide
(Amer Scientific Publishers, 2019-07-01)
Carbendazim (MBC) is a fungicide widely used in agriculture which allows the high productivity of several cultures, a necessary condition considering the growing of the world population. Moreover, MBC has environmental ...
Evidence of photoinduced lipid hydroperoxidation in Langmuir monolayers containing Eosin Y
(2018-11-01)
Photodynamic therapy (PDT) efficiency depends on many factors including the incorporation of the photosensitizer (PS) in cell membranes and possible lipid hydroperoxidation. In this study, we show that hydroperoxidation ...
Combining Experimental Evidence and Molecular Dynamic Simulations To Understand the Mechanism of Action of the Antimicrobial Octapeptide Jelleine-I
(Amer Chemical Soc, 2014-07-29)
Jelleines are four naturally occurring peptides that comprise approximately eight or nine C-terminal residues in the sequence of the major royal jelly protein 1 precursor (Apis mellifera). The difference between these ...
Modulation of peroxisomal and microsomal fatty acid oxidation by acetone. A comparative study between liver and kidney
(1998)
The effect of acetone consumption on some microsomal and peroxisomal activities was studied in rat kidney and these results were compared with data from former investigations in liver. Acetone increased the microsomal ...
Synthesis of coumarin derivatives as fluorescent probes for membrane and cell dynamics studies
(Elsevier, 2014)
Three coumarin-derived fluorescent probes, 3-acetyl-7-[(6-bromohexyl)oxy]-2H-chromen-2-one (FM1),
7-[(6-bromohexyl)oxy]-4-methyl-2H-chromen-2-one (FM2) and ethyl 2-{7-[(6-bromohexyl)oxy]-2-oxo-
2H-chromen-4-yl}acetate ...