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Peripheral mechanobiology of touch—studies on vertebrate cutaneous sensory corpuscles
(MDPI AG, 2020-08-27)
The vertebrate skin contains sensory corpuscles that are receptors for different qualities of mechanosensitivity like light brush, touch, pressure, stretch or vibration. These specialized sensory organs are linked anatomically ...
Fak Forms A Complex With Mef2 To Couple Biomechanical Signaling To Transcription In Cardiomyocytes
(Cell PressCambridge, 2016)
Mecanotransducción celular. Correlación entre las propiedades mecánicas y la organización-dinámica de proteínas de adhesión focal en células vivasCellular mechanotransduction. Correlation between mechanical properties and organization/dynamics of focal adhesion proteins in living cells
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2016)
TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling
(Nature Publishing Group, 2016-11)
Reactive oxygen species (ROS) produced by NADPH oxidase 2 (Nox2) function as key mediators of mechanotransduction during both physiological adaptation to mechanical load and maladaptive remodeling of the heart. This is ...
The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
(Elsevier Ireland, 2016-01)
Transient receptor potential channels have diverse roles in mechanosensation. Evidence is accumulating that members of the canonical subfamily of TRP channels (TRPC) are involved in touch and hearing. Characteristic features ...
Biosensors for studies on adhesion-mediated cellular responses to their microenvironment
(Frontiers Media, 2020-10)
Cells interact with their microenvironment by constantly sensing mechanical and chemical cues converting them into biochemical signals. These processes allow cells to respond and adapt to changes in their environment, and ...
The Cholinergic Lateral Line Efferent Synapse: Structural, Functional and Molecular Similarities With Those of the Cochlea
(Frontiers Media, 2021-10)
Vertebrate hair cell (HC) systems are innervated by efferent fibers that modulate their response to external stimuli. In mammals, the best studied efferent-HC synapse, the cholinergic medial olivocochlear (MOC) efferent ...
A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues
(Nature Publishing Group, 2020-04-28)
Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. However, testing these mechanical hypotheses on proteins ...
Wortmannin targeting phosphatidylinositol 3-kinase suppresses angiogenic factors in shear-stressed endothelial cells
(2020-06-01)
Modifications on shear stress-based mechanical forces are associated with pathophysiological susceptibility and their effect on endothelial cells (EC) needs to be better addressed looking for comprehending the cellular and ...