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Expression profile of BRCA1 and BRCA2 genes in premenopausal Mexican women with breast cancer: Clinical and immunohistochemical correlates
(2009)
Low BRCA1 gene expression is associated with increased invasiveness and influences the response of breast carcinoma (BC) to chemotherapeutics. However, expression of BRCA1 and BRCA2 genes has not been completely characterized ...
A utilização de inibidores de PARP na profilaxia e no tratamento do câncer de mama deficiente no gene BRCA1
(Instituto de Ciências da Saúde/ Universidade Federal da BahiaBrasil, 2010)
A enzima poli (ADP-ribose) polimerase-1 (PARP-1) representa um novo alvo importante na terapia-alvo do câncer. PARP-1
é essencial para o reparo de quebras no DNA via o reparo por excisão de base. Inibidores da PARP-1 têm ...
Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors.
(2008)
Germline mutations in BRCA1 account for a low proportion of hereditary cases in diverse populations. Several efforts have been made to find new genes involved in the inheritance of breast cancer with no success until today. ...
Critical role for BRCA1 expression as a marker of chemosensitivity response and prognosis
(Frontiers in Bioscience, 2016-01-01)
Chemotherapy is still the leader option for cancer treatment. Nevertheless some patients develop chemotherapy resistance. One major research goal is to identify the critical genes involved in chemotherapy response to predict ...
Estudio de factores genéticos para cáncer de mama en Colombia
(Universitas Médica, 2009-06-05)
Breast cancer is one of the main public health
problems, approximately 10% are genetic. In a
previous study carried out by our group, founder
mutations in BRCA1 and BRCA2 genes were
detected; this will allow early testing ...
BRCA1 and p53 regulate critical prostate cancer pathways
(Nature Publishing Group, 2013-09)
Background: Loss or mutations of the BRCA1 gene are associated with increased risk of breast and ovarian cancers and with prostate cancer (PCa) aggressiveness. Previously, we identified GADD153 as a target of BRCA1 protein, ...
DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis
(Sociedad de Biología de Chile, 2008)
Spectrum of BRCA1/2 point mutations and genomic rearrangements in high-risk breast/ovarian cancer Chilean families
(SPRINGER, 2011-04)
The distribution of BRCA1/2 germline mutations in breast/ovarian cancer (BC/OC) families varies among different populations. In the Chilean population, there are only two reports of mutation analysis of BRCA1/2, and these ...