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Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics
(Nature, 2020-02)
Neddylation is the post-translational protein modification most closely related to ubiquitination. Whereas the ubiquitin-like protein NEDD8 is well studied for its role in activating cullin−RING E3 ubiquitin ligases, little ...
A new non-canonical degron in Fragaria JAZ proteins shows functionality for jasmonate perception
(2018)
Jasmonates are phytohormones regulating development-related processes and defense responses. Jasmonoylisoleucine
(JA-Ile) is the bioactive jasmonate molecule mediating the interaction between the F-box protein COI1
(part ...
Plant Strategies To Control Growth And Development: Integration Of Both Signal Molecules, Auxin And Nitric Oxide
(Plos, 2018-08)
The term auxin is derived from the Greek word ?auxein,? which means to grow or to expand and 3 was sealed by Charles Darwin more than a century ago. In ?The Power of Movement in Plants? 4 (1880), Darwin first described the ...
Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor
(Wiley, 2020)
Skeletal muscle atrophy is characterized by the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. An increase in the expression of two muscle-specific E3 ligases, atrogin-1 and MuRF-1, and ...
Insulin Suppresses Atrophy- and Autophagy-related Genes in Heart Tissue and Cardiomyocytes Through AKT/FOXO Signaling
(2013-06-14)
Insulin is an important regulator of the ubiquitin-proteasome system (UPS) and of lysosomal proteolysis in cardiac muscle. However, the role of insulin in the regulation of the muscle atrophy-related Ub-ligases atrogin-1 ...
Insulin Suppresses Atrophy- and Autophagy-related Genes in Heart Tissue and Cardiomyocytes Through AKT/FOXO Signaling
(2013-06-14)
Insulin is an important regulator of the ubiquitin-proteasome system (UPS) and of lysosomal proteolysis in cardiac muscle. However, the role of insulin in the regulation of the muscle atrophy-related Ub-ligases atrogin-1 ...