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Septin 7 - Actin cross-organization is required for axonal association of Schwann cells
(2013)
Myelin sheaths present two distinct domains: compacted myelin spirals and fl anking non-compacted cytoplasmic channels, where lipid
and protein segregation is established by unknown mechanisms. Septins, a conserved family ...
Bacterial chemoreceptors of different length classes signal independently
(Wiley, 2014-08)
Bacterial chemoreceptors sense environmental stimuli and govern cell movement by transmitting the information to the flagellar motors. The highly conserved cytoplasmic domain of chemoreceptors consists in an alpha-helical ...
Intracellular localization of Arabidopsis sulfurtransferases
(AMER SOC PLANT BIOLOGISTS, 2004-06)
Sulfurtransferases (Str) comprise a group of enzymes widely distributed in archaea, eubacteria, and eukaryota which catalyze the transfer of a sulfur atom from suitable sulfur donors to nucleophilic sulfur acceptors. In ...
The viral transactivator HBx protein exhibits a high potential for regulation via phosphorylation through an evolutionarily conserved mechanism
(2012)
Background: Hepatitis B virus (HBV) encodes an oncogenic factor, HBx, which is a multifunctional protein that can
induce dysfunctional regulation of signaling pathways, transcription, and cell cycle progression, among ...
Old players with a newly defined function: Fra-1 and c-Fos support growth of human malignant breast tumors by activating membrane biogenesis at the cytoplasm
(Public Library of Science, 2013-01-02)
A shared characteristic of tumor cells is their exacerbated growth. Consequently, tumor cells demand high rates of phospholipid synthesis required for membrane biogenesis to support their growth. c-Fos, in addition to its ...
Mutational Replacements at the “Glycine Hinge” of the Escherichia coli Chemoreceptor Tsr Support a Signaling Role for the C-Helix Residue
(American Chemical Society, 2017-06)
Bacterial chemoreceptors are dimeric membrane proteins that transmit signals from a periplasmic ligand-binding domain to the interior of the cells. The highly conserved cytoplasmic domain consists of a long hairpin that ...
Nanoscale interactions between the nicotinic acetylcholine receptor and cholesterol
(Instituto de Histología y Embriología, 2021-06)
Cholesterol is a major lipid in biological membranes. It not only plays a structural role but also modulates a wide range of functional properties of neurotransmitter and hormone receptors and ion channels. The membraneembedded ...
Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003)
PDZK1, a multi-PDZ domain containing adaptor protein, interacts with various membrane proteins, including the high density lipoprotein (HDL) receptor scavenger receptor class B type I (SR-BI). Here we show that PDZK1 ...
Characterization of the human dynein light chain Rp3 and its use as a non-viral gene delivery vector
(SpringerNew YorkEUA, 2014)
Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus
(American Society for Biochemistry and Molecular Biology, 2004)
The tumor suppressor protein p53 is known to be transported to the nucleus along microtubular tracks by cytoplasmic dynein. However, the connection between p53 and the dynein motor protein complex has not been established. ...