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Piperine for treating breast cancer: A review of molecular mechanisms, combination with anticancer drugs, and nanosystems
(2022-01-01)
Piperine (PIP) is an alkaloid found primarily in Piper longum, and this natural compound has been shown to exert effects on proliferation and survival against various types of cancer. In particular, PIP has potent inhibitory ...
Molecular approaches to target heat shock proteins for cancer treatment
(Bentham Science Publishers, 2015)
HSP90 was the first molecular target to inhibit the interaction of this heat shock protein (HSP) with client proteins in cancer cells and tissues. The HSP90 inhibition was attempted to liberate from this chaperone the ...
Synergizing immunotherapy with molecularly targeted anticancer treatment
(Elsevier, 2014-09)
The therapeutic opportunity for anticancer kinase inhibitors (KIs) that block cell-signaling pathways is materializing. Yet, these molecular-targeted therapies are not tailored to be allies of the immune system, and often ...
Induction of micronuclei and toxic effects in embryos of pregnant rats treated before implantation with anticancer drugs: Cyclophosphamide, Cis‐platinum, adriamycin
(1990-01-01)
To evaluate a possible relationship of maternal exposure to anticancer drugs during the preimplantation period to blastopathies and postimplantation embryotoxicity, CD female rats were injected intraperitoneally on day 3 ...
Antiproliferative activity of the hexanic extract and phloroglucinols from Hypericum brasiliense
(Soc Brasileira FarmacognosiaCuritiba-prBrasil, 2013)
Citrinin against breast cancer: A cytogenotoxicological study
(2020-01-01)
Breast cancer is one of the most lethal types of cancer and a leading cause of mortality among Women worldwide. Citrinin (CIT), a polyketide extracted from the fungus Penicillium citrinum, exhibits a wide range of biological ...
Synthesis and Anticancer Properties of 'azole' based Chemotherapeutics as Emerging Chemical Moieties: A Comprehensive Review
(2020)
Azole frameworks serve as privileged scaffolds in the contemporary drug design paradigm owing to their unique physicochemical profile that promotes the development of highly selective, physiological benevolent chemotherapeutics. ...