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DNA nanoparticle-mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma
(Elsevier Science, 2013-04-28)
Thymulin has been shown to present anti-inflammatory and anti-fibrotic properties in experimental lung diseases. We hypothesized that a biologically active thymulin analog gene, methionine serum thymus factor, delivered ...
Participación de la cinasa de proteína C y la cinasa de tirosina en la hiperreactividad inducida por el leucotrieno D4 a la histamina en tiras de músculo liso traqueal de bovino
(2008-11-26)
RESUMEN: La hiperreactividad de las vías aéreas es un rasgo característico del asma, pero sus mecanismos no son bien conocidos. El leucotrieno D4 (LTD4) es una de las pocas moléculas capaces de producir hiperreactividad ...
Efectos de la administración de furosemida inhalada sobre la remodelación de la vía aérea en el modelo murino de asma inducido por ovoalbúmina
(Universidad Nacional Mayor de San MarcosPE, 2008)
La fisiopatología del asma se basa en inflamación y remodelación de las vías aéreas. La remodelación se encuentra determinada por los siguientes indicadores: pérdida del epitelio laminar, engrosamiento de la membrana ...
Aerobic conditioning and allergic pulmonary inflammation in mice. II. Effects on lung vascular and parenchymal inflammation and remodeling
(AMER PHYSIOLOGICAL SOC, 2008)
Vieira RP, de Andrade VF, Duarte AC, dos Santos AB, Mauad T, Martins MA, Dolhnikoff M, Carvalho CR. Aerobic conditioning and allergic pulmonary inflammation in mice. II. Effects on lung vascular and parenchymal inflammation ...
Pulmonary emphysema induced by passive smoking: an experimental study in rats
(Associação Brasileira de Divulgação Científica, 1997-10-01)
We describe a short time model for inducing experimental emphysema in rats by chronic tobacco smoke inhalation. Three groups of male Wistar rats (6 months old) were studied: controls (N = 8), rats intoxicated for 45 days ...
Cholinergic Hyperresponsiveness of Peripheral Lung Parenchyma in Chronic Obstructive Pulmonary Disease
(KARGER, 2011)
Background: Up to 60% of chronic obstructive pulmonary disease ( COPD) patients can present airway hyperresponsiveness. However, it is not known whether the peripheral lung tissue also shows an exaggerated response to ...
Reverse triggering dyssynchrony and its impact on diaphragm injury during mechanical ventilation.
(2020)
Mechanical ventilation (MV) is used to sustain life in patients admitted to the intensive care
unit for a wide spectrum of indications such as elective surgical procedures, septic shock,
multiple organic failure and acute ...
Effects of chronic L-NAME treatment lung tissue mechanics, eosinophilic and extracellular matrix responses induced by chronic pulmonary inflammation
(AMER PHYSIOLOGICAL SOC, 2008)
The importance of lung tissue in asthma pathophysiology has been recently recognized. Although nitric oxide mediates smooth muscle tonus control in airways, its effects on lung tissue responsiveness have not been investigated ...