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Na+/K+-ATPase stabilization by Hsp70 in the outer stripe of the outer medulla in rats during recovery from a low-protein diet
(Springer, 2008-02-19)
A low-protein (LP) diet induces injury from energy depletion in renal epithelial cells. Overexpression of heat-shock proteins has been implicated in the restoration of the cytoskeletal anchorage of Na+/K+-ATPase. We tested ...
A mutant ankyrin protein kinase from Medicago sativa affects Arabidopsis adventitious roots
(Csiro Publishing, 2008-12)
A family of plant kinases containing ankyrin-repeats, the Ankyrin-Protein Kinases (APKs), shows structural resemblance to mammalian Integrin-Linked Kinases (ILKs), key regulators of mammalian cell adhesion. MsAPK1 expression ...
Neurotoxicity of the pesticide rotenone on neuronal polarization: A mechanistic approach
(Shenyang Editorial Dept Neural Regeneration Res, 2019-05)
Neurons are the most extensive and polarized cells that display a unique single long axon and multiple dendrites, which are compartments exhibiting structural and functional differences. Polarity occurs early in neuronal ...
Gamma oscillations in the pedunculopontine nucleus are regulated by F-actin: neuroepigenetic implications
(American Physiological Society, 2020-02)
The pedunculopontine nucleus (PPN) is part of the reticular activating system (RAS) in charge of arousal and rapid eye movement sleep. The presence of high-frequency membrane oscillations in the gamma-band range in the PPN ...
GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration
(Public Library of Science, 2012-12)
The regulation of cell migration is a highly complex process that is often compromised when cancer cells become metastatic. The microtubule cytoskeleton is necessary for cell migration, but how microtubules and ...
Global daily dynamics of the pineal transcriptome
(Springer, 2011-02-08)
Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases. A set of over 600 ...
Polycystin-2 (TRPP2) regulation by Ca2+ is effected and diversified by actin-binding proteins
(Cell Press, 2015-05)
Calcium regulation of Ca2+-permeable ion channels is an important mechanism in the control of cell function. Polycystin-2 (PC2, TRPP2), a member of the transient receptor potential superfamily, is a nonselective cation ...
Sex-steroid rapid action and its role in invasiveness and metastasis of breast cancer
(Springer, 2012)
Sex steroids, particularly estrogen and progesterone, promote normal breast tissue growth and differentiation. Prolonged exposure of estrogen and/or progesterone is well-documented to be the risk factor for breast cancer ...
Gangliosides in Axon Stability and Regeneration
(Elsevier, 2018)
Gangliosides are a family of sialic acid-containing glycosphingolipids highly expressed in the nervous system of vertebrates. Over the last 25years, research has unmasked several of their neurobiological functions but the ...
Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells
(Impact Journals, 2018-05-04)
Triple-negative breast cancer (TNBC) is associated with poor prognosis, high local recurrence rate and high rate of metastasis compared with other breast cancer subtypes. In addition, TNBC lacks a targeted therapy. This ...