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Prominin-1 (CD133) modulates the architecture and dynamics of microvilli
(Wiley Blackwell Publishing, Inc, 2018-11-14)
Prominin-1 is a cell surface biomarker that allows the identification of stem and cancer stemcells from different organs. It is also expressed in several differentiated epithelial and non-epithelial cells. Irrespective of ...
The dynamics of intracellular water constrains glycolytic oscillations in Saccharomyces cerevisiae
(Nature Publishing Group, 2017-12-24)
We explored the dynamic coupling of intracellular water with metabolism in yeast cells. Using the polarity-sensitive probe 6-acetyl-2-dimethylaminonaphthalene (ACDAN), we show that glycolytic oscillations in the yeast S. ...
Role of testosterone in the intrinsic apoptotic pathway of skeletal muscle
(Elsevier Science Inc, 2011-06)
Apoptosis is a systematic set of events that results in cellular self-destruction without inflammation or damage to the surrounding tissue. Experimental animal data indicate that apoptosis is activated in the aged skeletal ...
Trypanosoma cruzi Bromodomain Factor 3 Binds Acetylated α-Tubulin and Concentrates in the Flagellum during Metacyclogenesis
(American Society For Microbiology, 2014-04)
Bromodomains are highly conserved acetyl-lysine binding domains found mainly in proteins associated with chromatin and nuclear acetyltransferases. The Trypanosoma cruzi genome encodes at least four bromodomain factors ...
Design, Synthesis, and Characterization of Novel sn-1 Heterocyclic DAG-Lactones as PKC Activators
(American Chemical Society, 2021-08)
DAG-lactones represent useful templates for the design of potent and selective C1 domain ligands for PKC isozymes. The ester moiety at the sn-1 position, a common feature in this template, is relevant for C1 domain ...
Changes of myoid and endothelial cells in the peritubular wall during contraction of the seminiferous tubule
(Springer, 2016)
The wall of the seminiferous tubule in rodents consists of an inner layer of myoid cells covered by an outer layer of endothelial cells. Myoid cells are a type of smooth muscle cell containing α-actin filaments arranged ...
Contribution of microscopy for understanding the mechanism of action against trypanosomatids
(Springer International Publishing, 2018)
Transmission electron microscopy (TEM) has proved to be a useful tool to study the ultrastructural alterations and the target organelles of new antitrypanosomatid drugs. Thus, it has been observed that sesquiterpene lactones ...
Biological effects of a complex of vanadium(V) with salicylaldehyde semicarbazone in osteoblasts in culture: Mechanism of action
(Elsevier Science Inc, 2009-04-01)
Vanadium compounds display important pharmacological actions in vivo and in vitro systems. Semicarbazones are versatile ligands with therapeutic effects. Herein, we report the effects of VVO2(salicylaldehydesemicarbazone) ...
Characterization of the B-Raf interactome in mouse hippocampal neuronal cells
(Elsevier Science, 2011-02)
B-Raf links a variety of extracellular stimuli downstream of cell surface receptors, constituting a determining factor in the ability of neurons to activate ERK. A detailed study of the B-Raf interactome is necessary to ...
Mechanisms of Resistance to Photodynamic Therapy: An Update
(Springer, 2015)
Photodynamic Therapy (PDT) involves the combination of light andphotosensitizer (PS). Therefore, it is possible for cells to develop resistance basedon the doses of PS used or the light dose. The data compiled by several ...