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Mostrando ítems 61-70 de 253
Long-term exposure to MST-312 leads to telomerase reverse transcriptase overexpression in MCF-7 breast cancer cells
(Lippincott, Williams & Wilkins, 2017)
Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia
(NATL ACAD SCIENCES, 2009)
Loss-of-function mutations in telomerase complex genes can cause bone marrow failure, dyskeratosis congenita, and acquired aplastic anemia, both diseases that predispose to acute myeloid leukemia. Loss of telomerase function ...
Oxoisoaporphines and aporphines: Versatile molecules with anticancer Efects
(MDPI, 2020)
Cancer is a disease that involves impaired genome stability with a high mortality index globally. Since its discovery, many have searched for effective treatment, assessing different molecules for their anticancer activity. ...
Avaliação do potencial terapêutico in vitro de inibidor de telomerase MST-312 em linhagens celulares de câncer de mama
(2017-01-04)
As células normais tem potencial proliferativo regulado, e na maioria dos tipos celulares, obedecem a um número determinado de ciclos. Para que uma célula possa proliferar indefinidamente e de forma autônoma e ser considerada ...
Telomere and telomerase: Brief review of a history initiated by Hermann Müller and Barbara McClintock
What is the nature of the biological clock that determines the cells aging? What is the way to explain the genesis of diseases associated in aging? The above are only some of the questions whose answer could be found within ...
Vascular dysfunction by myofibroblast activation in patients with idiopathic pulmonary fibrosis and prognostic significance
(ASSOC BRAS DIVULG CIENTIFICASAO PAULO, 2012)
In this study, we demonstrated the importance of telomerase protein expression and determined the relationships among telomerase, endothelin-1 (ET-1) and myofibroblasts during early and late remodeling of parenchymal and ...
Synthesis of Dihydroindolo[2,3-c]carbazole as Potential Telomerase Inhibitor
(Journal of Heterocyclic Chemistry vol.53 no.3 762-766 2015, 2015-05-27)
The dictyodendrins A-E were the first marine natural products that show inhibition of telomerase. A versatile and convergent route was described for the synthesis of derivatives of these pyrrolo[2,3-c]carbazole alkaloids ...
Neuroprotective effects of the catalytic subunit of telomerase : A potential therapeutic target in the central nervous system
(2016-07-01)
Senescence plays an important role in neurodegenerative diseases and involves key molecular changes induced by several mechanisms such as oxidative stress, telomere shortening and DNA damage. Potential therapeutic strategies ...