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Sphingolipid pathway as a biosensor of cancer chemosensitivity: a proof of principle
(2022-12)
Cancer is a complex genetic disease with reduced treatment alternatives due to tumor heterogeneity and
drug multiresistance emergence. The sphingolipid (SL) metabolic pathway integrates different responses
of cellular ...
Characterization of sphingolipids from mycopathogens: Factors correlating with expression of 2-hydroxy fatty acyl (E)-Delta(3)-unsaturation in cerebrosides of Paracoccidioides brasiliensis and Aspergillus fumigatus
(Amer Chemical Soc, 1999-06-01)
Significant differences exist between mammals and fungi with respect to glycosphingolipid (GSL) structure and biosynthesis. Thus, these compounds, as well as the cellular machinery regulating their expression, have ...
Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids
(American Society for Microbiology, 2018)
Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids
(American Society for Microbiology, 2015)
The many faces (and phases) of ceramide and sphingomyelin I – single lipids
(Springer Verlag, 2017-10)
Ceramides, the simplest kind of two-chained sphingolipids, contain a single hydroxyl group in position 1 of the sphingoid base. Sphingomyelins further contain a phosphocholine group at the OH of position 1 of ceramide. ...
The many faces (and phases) of ceramide and sphingomyelin II – binary mixtures
(Springer Verlag, 2017-10)
A rather widespread idea on the functional importance of sphingolipids in cell membranes refers to the occurrence of ordered domains enriched in sphingomyelin and ceramide that are largely assumed to exist irrespective of ...
Elovl4 and Fa2h expression during rat spermatogenesis: a link to the very-long-chain PUFAs typical of germ cell sphingolipids
(American Society for Biochemistry and Molecular Biology, 2018-05-03)
The sphingolipids (SLs) of rodent spermatogenic cells (spermatocytes, spermatids) and spermatozoa contain nonhydroxylated and 2-hydroxylated versions of very-long-chain (C26-C32) PUFAs (n-V and h-V, respectively) not present ...
Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration
(Public Library of Science, 2018-08)
Sphingolipids are bioactive molecules associated with oxidative stress, inflammation, and neurodegenerative diseases, but poorly studied in the context of age-related macular degeneration (AMD), a prevalent sight-threatening ...