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Regioquímica da reação de alquilação entre 4- (trialometil)pirimidin-2(1h)-onas e 5-bromoenonas
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2022-09-23)
The present thesis reports the reactivity study between 5-bromo-1,1,1,-trifluoro-4-
methoxy(amino)pent-3-en-2-ones (5-bromoenones/enaminones) towards 5- or 6-
substituted 4-(trihalomethyl)pyrimidin-2(1H)-ones. During the ...
Major roles of for pyrimidine dimers, nucleotide excision repair and ATR in the alternative splicing response to UV irradiation
(Elsevier B.V., 2017-03-21)
We have previously found that UV irradiation promotes RNA polymerase II (RNAPII) hyperphosphorylation and subsequent changes in alternative splicing (AS). We show now that UV-induced DNA damage is not only necessary but ...
Antiviral activity of A771726, the active metabolite of leflunomide, against Junín virus
(Wiley-liss, Div John Wiley & Sons Inc, 2018-05)
The aim of this study was to investigate the effect of A771726, the active metabolite of leflunomide, (CONICET-UBA), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad against the infection with ...
Pirimidinas: de potenciais fármacos a marcadores fluorescentes
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Ciencias Farmaceuticas, 2017)
Intra- and extra-cellular DNA damage by harmine and 9-methyl-harmine
(Elsevier, 2014-01)
It is known that β-carbolines are able to produce photosensitized damage in cell-free DNA, but there is little information on their effects on cellular DNA. Therefore, we have analyzed the DNA damage produced by harmine ...
Chemical Constituents From The Stem Bark Of Annona Pickelii (annonaceae)
(SOC BRASILEIRA QUIMICASAO PAULO, 2015)
Intra- and extracellular DNA damage by harmine and 9-methyl-harmine
(Elsevier Science Sa, 2014-02-13)
It is known that b-carbolines are able to produce photosensitized damage in cell-free DNA, but there is little information on their effects on cellular DNA. Therefore, we have analyzed the DNA damage produced by harmine ...