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Protein interactors of the cellular tumor antigen p53 with response to ionizing radiation
(LimaPE, 2014-01)
TP53 interacts with the genes CDKN1A, CSNK1A1, CSNK1D, BAX, ATM, MDM2, HIF1A,SP1. This consensus network has many binding regions involved in phosphorylation. To find whether or not the interactions are involved in ionizing ...
Determinación de nuevos principios y elementos de diseño biomoleculares y su aplicación en sistemas de interés terapéutico
(2018-11-05)
El trabajo realizado en esta tesis surge del reconocimiento explícito de que la comprensión detallada de la modulación local que sufren distintas interacciones no covalentes en ambientes de dimensiones nanométricas resulta ...
ATP Induces IL-1 beta Secretion in Neisseria gonorrhoeae-Infected Human Macrophages by a Mechanism Not Related to the NLRP3/ASC/Caspase-1 Axis
(Hindawi, 2016)
Neisseria gonorrhoeae (Ngo) has developed multiple immune evasion mechanisms involving the innate and adaptive immune responses. Recent findings have reported that Ngo reduces the IL-1 beta secretion of infected human ...
Utilização de processos industriais no desenvolvimento de coagulante orgânico à base de moringa oleifera para área de saneamento
(Universidade Tecnológica Federal do ParanáCampo MouraoBrasilPrograma de Pós Graduação em Inovações TecnológicasUTFPR, 2020-02-28)
Coagulation and flocculation processes are the main processes in water treatment and are responsible for removing more than 90% of contaminants present in raw water. However, the most used chemical coagulating agent, ...
Inflammatory breast cancer: Clinical implications of genomic alterations and mutational profiling
(2020-10-01)
Inflammatory breast cancer (IBC) is a rare and aggressive type of breast cancer whose molecular basis is poorly understood. We performed a comprehensive molecular analysis of 24 IBC biopsies naïve of treatment, using a ...