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Papel do fator de troca de nucleotídeos guanina RasGEF1b na resposta imune ao protozoário parasito Trypanosoma cruzi
(Universidade Federal de Minas GeraisBrasilPrograma de Pós-Graduação em Biologia CelularUFMG, 2018-04-27)
Trypanosoma cruzi, the causative agent of Chagas disease, activates receptors present on cells of innate immunity, such as Toll-like receptors. Intracellular signaling triggered in cells such as macrophages and cardiomyocytes ...
Overexpression of the Tomato Pollen Receptor Kinase LePRK1 Rewires Pollen Tube Growth to a Blebbing Mode
(American Society of Plant Biologist, 2014-09)
The tubular growth of a pollen tube cell is crucial for the sexual reproduction of flowering plants. LePRK1 is a pollen-specific and plasma membrane–localized receptor-like kinase from tomato (Solanum lycopersicum). LePRK1 ...
Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum
(Facultad de Medicina y CienciaCentro de Biología Celular y Biomedicina CEBICEM, 2019)
Maintaining the optimal performance of cell processes and organelles is the task of auto-regulatory systems. Here we describe an auto-regulatory device that helps to maintain homeostasis of the endoplasmic reticulum (ER) ...
FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
(Elsevier, 2021-11)
Despite the undisputable role of the small GTPase Rac1 in the regulation of actin cytoskeleton reorganization, the Rac guanine-nucleotide exchange factors (Rac-GEFs) involved in Rac1-mediated motility and invasion in human ...
Evidence in Favor of an Alternative Glucocorticoid Synthesis Pathway During Acute Experimental Chagas Disease
(Frontiers Media, 2020-01)
It is well-established that infectious stress activates the hypothalamus–pituitary–adrenal axis leading to the production of pituitary adrenocorticotropin (ACTH) and adrenal glucocorticoids (GCs). Usually, GC synthesis is ...
Evidence in Favor of an Alternative Glucocorticoid Synthesis Pathway During Acute Experimental Chagas Disease
(Frontiers Media, 2020-01)
It is well-established that infectious stress activates the hypothalamus–pituitary–adrenal axis leading to the production of pituitary adrenocorticotropin (ACTH) and adrenal glucocorticoids (GCs). Usually, GC synthesis is ...
Análise dos níveis proteicos de RasGEF1b e do seu papel sobre a regulação da ativação de NF-kappaB em macrófagos estimulados com agonistas de receptores do tipo Toll (TLRs)
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Biologia CelularUFMG, 2012-07-23)
RasGEF1b, a guanine nucleotide exchange factor, was described initially as the first example of a GEF whose expression is induced by inflammatory agonists of Toll- like receptors (TLRs). As RasGEF1b expression studies have ...
Mecanismos da regulação transcricional de Rasgef1b, um gene induzível por receptores do tipo Toll
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Biologia CelularUFMG, 2019-07-29)
The guanine-nucleotide exchange factor RasGEF1b is encoded by a gene whose expression is induced in innate immune cells in response to the activation of Toll-like receptors (TLRs). Its mRNA accumulates in human and mouse ...