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Influência das condições de alimentação de glicerol e ornitina na produção de ácido clavulânico por Streptomyces clavuligerus
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Engenharia Química - PPGEQ, 2008-03-26)
The clavulanic acid (CA) is a powerful inhibitor of β-lactamases, enzymes that clives the β-
lactam ring of penicillins and cephalosporins, inactivating these compounds. CA is
traditionally produced by Streptomyces ...
High-cell-density poly (3-hydroxybutyrate) production from sucrose using Burkholderia sacchari culture in airlift bioreactor
Burkholderia sacchari IPT 189 poly (3-hydroxybutyrate) (P3HB) production in airlift bioreactor were
investigated in batch and fed-batch culture using sucrose as carbon source. In batch experiments it
was observed that ...
Otimização da produção de etanol 2G a partir de hexoses e pentoses
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Engenharia Química - PPGEQ, 2014-02-27)
The industrial production of fuel ethanol and sugar generates the main byproduct of sugarcane bagasse, which is burned in boilers for power generation. However, as a lignocellulosic material (consisting basically of three ...
Cloning, expression and optimized production in a bioreactor of bovine chymosin B in Pichia (Komagataella) pastoris under AOX1 promoter
(Academic Press Inc Elsevier Science, 2013-12)
The codon sequence optimized bovine prochymosin B gene was cloned under the control of the alcohol oxidase 1 promoter (AOX1) in the vector pPIC9K and integrated into the genome of the methylotrophic yeast Pichia (Komagataella) ...
Alternative low-cost process for large-scale production of Bacillus thuringiensis in a simple and novel culture system
(Taylor & Francis, 2018-11)
An industrial-scale, profitable method for production of the most widely used bioinsecticide, Bacillus thuringiensis (Bt), is challenging because of its widespread application. The aim of this study is to present a strategy ...
Rational design of a culture medium for the intensification of lipid storage in Chlorella sp. Performance evaluation in air-lift bioreactor
(Elsevier, 2014-02)
An optimal medium to culture Chlorella sp., microalgae capable of storage intracellular lipids was obtained. This culture medium consists of a saline base plus carbon-energy and nitrogen sources. Significant factors exerting ...
Bioprocess and downstream optimization of recombinant bovine chymosin B in Pichia (Komagataella) pastoris under methanol-inducible AOXI promoter
(Academic Press Inc Elsevier Science, 2014-09)
A clone of the methylotrophic yeast Pichia pastoris strain GS115 transformed with the bovine prochymosin B gene was used to optimize the production and downstream of recombinant bovine chymosin expressed under the ...
Sliding mode scheme for adaptive specific growth rate control in biotechnological fed-batch processes
(Taylor & Francis Ltd, 2007-02)
This paper addresses the control of biomass growth rate in fed-batch bioreactors. The main difficulty when designing controllers for these processes is the lack of accurate on-line knowledge of the controlled variable as ...
Optimal design of dynamic experiments in the development of cybernetic models for bioreactors
(Institution of Chemical Engineers, 2018-08)
Cybernetic models of bioreactors are appealing due to their capacity to account for regulatory mechanisms in cell metabolism by modeling the synthesis of enzymes and their activities. For a given objective of interest, ...