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Binding of [Cr(phen)3]3+to transferrin at extracellular and endosomalpHs: Potential application in photodynamic therapy
(Elsevier Science, 2014-06)
Background Transferrin is an iron-binding blood plasma glycoprotein that controls the level of free iron in biological fluids. This protein has been deeply studied in the past few years because of its potential use as a ...
Structural and functional abnormalities in the olfactory system of fragile x syndrome models
(Frontiers Media S.A., 2019)
Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1
(2000-03-25)
The crystal structures of five new non-electrophilic β-strand-templated thrombin active-site inhibitors have been determined bound to the enzyme. Four co-crystallize with hirugen and inhibitor isomorphously to produce ...
Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1
(2000-03-25)
The crystal structures of five new non-electrophilic β-strand-templated thrombin active-site inhibitors have been determined bound to the enzyme. Four co-crystallize with hirugen and inhibitor isomorphously to produce ...
Virtual screening and its integration with modern drug design technologies
(Bentham Science PublishingSharjah, 2008-01)
Drug discovery is a highly complex and costly process, which demands integrated efforts in several relevant aspects involving innovation, knowledge, information, technologies, expertise, R&D investments and management ...
Analysis of agonist and antagonist effects on thyroid hormone receptor conformation by hydrogen/deuterium exchange
(2011-01-01)
Thyroid hormone receptors (TRs) are ligand-gated transcription factors with critical roles in development and metabolism. Although x-ray structures of TR ligand-binding domains (LBDs) with agonists are available, comparable ...
Analysis of agonist and antagonist effects on thyroid hormone receptor conformation by hydrogen/deuterium exchange
(2011-01-01)
Thyroid hormone receptors (TRs) are ligand-gated transcription factors with critical roles in development and metabolism. Although x-ray structures of TR ligand-binding domains (LBDs) with agonists are available, comparable ...
Easy and fast method for expression and native extraction of Plasmodium vivax Duffy binding protein fragments
(2018)
Background: The Plasmodium vivax Duffy binding protein (PvDBP) has been the most studied ligand binding human reticulocytes to date. This molecule has a cysteine-rich domain in region II (RII) which has been used as control ...