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Produção recombinante e estudos funcionais de três novas cistatinas da cana-de-açúcar e sua utilização em estudos de inibição da adesão, proliferação, migração e invasão celular
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Genética Evolutiva e Biologia Molecular - PPGGEv, 2008-02-29)
ABSTRACT
Tumor metastasis is usually a major cause of death among cancer patients.
Degradation and invasion of the extracellular matrix and basement membrane, key
steps in the metastatic process, rely on the activity of ...
A novel type 1 cystatin involved in the regulation of Rhipicephalus microplus midgut cysteine proteases
(Elsevier, 2020-05)
Rhipicephalus microplus is a cattle ectoparasite found in tropical and subtropical regions around the world with great impact on livestock production. R. microplus can also harbor pathogens, such as Babesia sp. and Anaplasma ...
Inhibition of Plasmodium falciparum cysteine proteases by the sugarcane cystatin CaneCPI-4
(Elsevier Ireland Ltd, 2018)
Malaria is a disease caused by Plasmodium parasites that affects hundreds of millions of people. Plasmodium proteases are involved in invasion, erythrocyte egress and degradation of host proteins. Falcipains are well studied ...
Cistatina C e taxa de filtração glomerular em cirurgia cardíaca com circulação extracorpórea
(Sociedade Brasileira de Cirurgia Cardiovascular, 2009-09-01)
OBJETIVO: Avaliar a cistatina C como marcador de função renal em pacientes submetidos à cirurgia de cardíaca com circulação extracorpórea, comparando com a dosagem sérica de creatinina. MÉTODOS: Foram analisados 50 pacientes ...
Bmeystatin, a cysteine proteinase inhibitor characterized from the tick Boophilus microplus
(Elsevier B.V., 2006-08-18)
The bovine tick Rhipicephalus (Boophilus) microplus is a blood-sucking animal, which is responsible for Babesia spp and Anaplasma marginale transmission for cattle. From a B. microplus fat body cDNA library, 465 selected ...
Kinetic characterization of a novel cysteine peptidase from the protozoan Babesia bovis, a potential target for drug design
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2020-12)
C1A cysteine peptidases have been shown to play an important role during apicomplexan invasion and egress of host red blood cells (RBCs) and therefore have been exploited as targets for drug development, in which peptidase ...
Rmcystatin3, a cysteine protease inhibitor from Rhipicephalus microplus hemocytes involved in immune response
(Elsevier B.V., 2014-11-01)
The Rhipicephalus microplus tick is responsible for losses in the livestock production estimated in 2 billions USD. Despite its economical importance the knowledge in tick's physiology is sparse. in order to contribute to ...