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Laminin-derived peptide AG73 regulates migration, invasion, and protease activity of human oral squamous cell carcinoma cells through syndecan-1 and beta 1 integrin
(SPRINGER, 2010)
Squamous cell carcinoma is a prevalent head and neck tumor with high mortality. We studied the role played by laminin alpha 1 chain peptide AG73 on migration, invasion, and protease activity of cells (OSCC) from human oral ...
Application of force to a syndecan-4 containing complex with thy-1 alpha (v) beta (3) integrin accelerates neurite retraction
(Frontiers Media, 2020)
Inflammation contributes to the genesis and progression of chronic diseases, such as cancer and neurodegeneration. Upregulation of integrins in astrocytes during inflammation induces neurite retraction by binding to the ...
Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation
(Biomed Central Ltd, 2013-03-25)
Background: Anoikis resistance is one of the abilities acquired along tumor progression. This characteristic is associated with metastasis development, since tumorigenic cells must survive independently of cell-matrix ...
The integrin binding peptide, atn-161, as a novel therapy for SARS-CoV-2 infection
Many efforts to design and screen therapeutics for the current severe acute respiratory
syndrome coronavirus (SARS-CoV-2) pandemic have focused on inhibiting viral host cell entry
by disrupting ACE2 binding with the ...
Histoplasma capsulatum-Induced Cytokine Secretion in Lung Epithelial Cells Is Dependent on Host Integrins, Src-Family Kinase Activation, and Membrane Raft Recruitment
(Frontiers Media Sa, 2016)
Histoplasma capsulatum var. capsulatum is a dimorphic fungus that causes histoplasmosis, a human systemic mycosis with worldwide distribution. In the present work, we demonstrate that H. capsulatum yeasts are able to induce ...
The effect of DMSA-functionalized magnetic nanoparticles on transendothelial migration of monocytes in the murine lung via a beta(2) integrin-dependent pathway
(ELSEVIER SCI LTD, 2010)
Magnetic nanoparticles surface-functionalized with meso-2,3-dimercaptosuccinic acid (MNPs-DMSA) constitute an innovative and promising approach for tissue- and cell-targeted delivery of therapeutic drugs in the lung. ...
Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration
(Elsevier, 2016)
Our previous reports indicate that ligand-induced alpha(v)beta(3) integrin and Syndecan-4 engagement increases focal adhesion formation and migration of astrocytes. Additionally, ligated integrins trigger ATP release through ...
Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration
(2016)
Our previous reports indicate that ligand-induced alpha(v)beta(3) integrin and Syndecan-4 engagement increases focal adhesion formation and migration of astrocytes. Additionally, ligated integrins trigger ATP release through ...
Characterization of alpha X I-domain binding to Thy-1
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005-06-03)
The β 2 integrins are found exclusively in leukocytes and they are composed of a common β chain, CD18, and one of four unique α chains, CD11a (α L subunit), CD11b (α M subunit), CD11c (α ...