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Sequence determination and homology modeling of lipase from Marinobacter sp. LBDeterminación de secuencia y modelaje por homología de la lipasa de Marinobacter sp. LB
(Universidad Nacional Mayor de San Marcos, Facultad de Ciencias Biológicas, 2018)
Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) gamma Activators and Pan-PPAR Partial Agonists
(Public Library Science, 2012-05-23)
Thiazolidinediones (TZDs) act through peroxisome proliferator activated receptor (PPAR) gamma to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these ligands mean that selective modulators ...
Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities
(2003-10)
BaP1 is a 22.7-kD P-I-type zinc-dependent metalloproteinase isolated from the venom of the snake Bothrops asper, a medically relevant species in Central America. This enzyme exerts multiple tissue-damaging activities, ...
Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities
(2003-10)
BaP1 is a 22.7-kD P-I-type zinc-dependent metalloproteinase isolated from the venom of the snake Bothrops asper, a medically relevant species in Central America. This enzyme exerts multiple tissue-damaging activities, ...
The druggable pocketome of Corynebacterium diphtheriae: A new approach for in silico putative druggable targets
(Frontiers Research Foundation, 2018-02)
Diphtheria is an acute and highly infectious disease, previously regarded as endemic in nature but vaccine-preventable, is caused by Corynebacterium diphtheriae (Cd). In this work, we used an in silico approach along the ...
Two novel unstable hemoglobin variants due to in-frame deletions of key amino acids in the β-globin chain
(Wiley Blackwell Publishing, Inc, 2018-06)
Hemoglobinopathies are the most common autosomal recessive disorders and are mostly inherited in a recessive manner. However, certain mutations can affect the globin chain stability, leading to dominant forms of thalassemia. ...
Fluorinated oxysterol analogues: Synthesis, molecular modelling and LXRβ activity
(Pergamon-Elsevier Science Ltd, 2017-01)
Liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional control of lipid metabolism. The ability of LXRs to integrate metabolic and inflammation signalling makes them attractive targets ...
Anandamide revisited: How cholesterol and ceramides control receptor-dependent and receptor-independent signal transmission pathways of a lipid neurotransmitter
(MDPI, 2018-06)
Anandamide is a lipid neurotransmitter derived from arachidonic acid, a polyunsaturated fatty acid. The chemical differences between anandamide and arachidonic acid result in a slightly enhanced solubility in water and ...
Reverse Engineering of an Aspirin-Responsive Transcriptional Regulator in Escherichia coli
(American Chemical Society, 2019-07)
Bacterial transcription factors (TFs) are key devices for the engineering of complex circuits in many biotechnological applications, yet there are few well-characterized inducer-responsive TFs that could be used in the ...
Activity Cliff como ferramenta na análise da relação estrutura atividade em uma série de inibidores da enzima FabH bacteriana
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS FARMACÊUTICAS, 2018-05-30)
The synthesis of fatty acids, mainly by the enzyme β-ketoacyl-ACP synthase III (FabH), has been
emerging as an excellent target for new molecules with antimicrobial action. Despite the urgency
generated by increasing ...