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Geographical Distribution of Pyrethroid Resistance Allele Frequency in Head Lice (Phthiraptera: Pediculidae) From Argentina
(Entomological Society of America, 2013-09)
The human head louse, Pediculus humanus capitis De Geer (Phthiraptera: Pediculidae), is an obligate ectoparasite that causes pediculosis capitis and has parasitized humans since the beginning of humankind. Head louse ...
Kdr mutations in Triatoma infestans from the Gran Chaco are distributed in two differentiated foci: Implications for pyrethroid resistance management
(Elsevier Science, 2016-06)
Point mutations in the voltage-gated sodium channel, the primary target of pyrethroid insecticides, have been associated with the resistance in Triatoma infestans, an important vector of Chagas' disease. Hence, the ...
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor
(Lippincott Williams, 2007-12)
Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies. We studied its possible interaction with channels other than its known therapeutic target, the voltage-gated sodium channel, using the ...
A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS plus ) mutation
(Elsevier B.V., 2009-07-01)
Mutations in the voltage-gated sodium channel SCN1A are responsible for a number of seizure disorders including Generalized Epilepsy with Febrile Seizures Plus (GEFS+) and Severe Myoclonic Epilepsy of Infancy (SMEI). To ...
Modelagem estrutural do canal de sódio 1.4 e estudo teórico da ligação de alfa e beta toxinas de escorpião
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em BioinformaticaUFMG, 2019-01-30)
Voltage-gated sodium channels (VGSD) are proteins responsible for the propagation
of information between neurons, skeletal muscle fibers, cardiac muscle fibers and other types
of excitable cells. They are rapidly activated ...
Amiloride-sensitive epithelial Na+ channels reconstituted into planar lipid bilayer membranes
(1984)
High resistance epithelia actively transport sodium from the luminal side to the blood. Aldosterone and vasopressin stimulate this sodium transport system; the diuretic drug amiloride inhibits it in a reversible fashion. ...
Geração e caracterização molecular de anticorpos contra canais para sódio voltagem dependentes
(Universidade Federal de Minas GeraisUFMG, 2012-11-05)
Voltage-gated sodium channels (Nav) are ion channels responsible for the initiation and propagation of action potentials in electrically excitable cells. These channels are expressed in metastatic cells of several types ...
Nav1.5 cardiac sodium channels, regulation and clinical implications
(Universidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina, 2014-10-01)
Voltage-gated sodium channels constitute a group of membrane proteins widely distributed thought the body. In the heart, there are at least six different isoforms, being the Nav1.5 the most abundant. The channel is composed ...
Caracterización farmacológica de toxinas bunodosoma sobre canales de sodio dependientes de voltaje mamíferos
(2007)
Voltaje de canales de sodio dependientes representan un importante objetivo para diferentes neurotoxinas y allí se han identificado diferentes sitios según estas interacciones de Unión. Las llamadas toxinas de sitio 3 ...