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The receptor-dependent LQTA-QSAR: application to a set of trypanothione reductase inhibitors
(SpringerDordrechtHolanda, 2012)
Glutathione metabolism in protozoan parasites : making the difference
(Nova Science Publishers, 2013)
Generation of reactive oxygen species (ROS) is a common feature of abiotic and biotic stresses. ROS need to be detoxified to avoid the occurrence of deleterious reactions. Parasitic diseases such as sleeping sickness, ...
Kinetic studies reveal a key role of a redox-active glutaredoxin in the evolution of the thiol-redox metabolism of trypanosomatid parasites
(American Society for Biochemistry and Molecular Biology, 2019)
Trypanosomes are flagellated protozoan parasites (kinetoplastids) that have a unique redox metabolism based on the small dithiol trypanothione (T(SH)2). Although GSH may still play a biological role in trypanosomatid ...
Trypanosoma cruzi: effect and mode of action of nitroimidazole and nitrofuran derivatives
(PERGAMON-ELSEVIER SCIENCE, 2003-03-15)
With the aim of determining the actual target(s) of nitro-group bearing compounds considered as possible leads for the development of drugs against Chagas' disease, we studied in parallel nitrofurans and nitroimidazoles. ...
Análisis de polimorfismos en los genes tripanotión reductasa y cruzipaína en cepas colombianas de Trypanosoma cruziAnalysis of polymorphisms in the trypanothione reductaseand cruzipaingenes inColombian strains of Trypanosoma cruzi
(Instituto Nacional de SaludBiología y Control de Enfermedades InfecciosasGenética Molecular (GENMOL)Bogotá, Colombia, 2022)