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Mostrando ítems 61-70 de 3819
Estudos de medicamentos biosimilares
(2010-09-01)
In Brazil, the registration of new drugs is carried out only when the regulatory agency (Anvisa, acronym in Portuguese) is fully satisfied with the evidence of their quality, efficacy and safety, presented by a pharmaceutical ...
A phase II multicenter randomized study to evaluate the safety and efficacy of combining thermotherapy and a short course of miltefosine for the treatment of uncomplicated cutaneous leishmaniasis in the New World.
(Public Library of Science, 2022)
Background: Systemic pentavalent antimonials, mainly meglumine antimoniate, continue to be the first-choice drugs for treatment of cutaneous leishmaniasis (CL) despite their toxicity, difficulty of administration and high ...
Therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas
(Oxford University Press, 2013-05)
Background: Metronomic chemotherapy (MCT) refers to the chronic and equally spaced administration of low doses of different chemotherapy drugs, without extended rest periods. Herein, we investigated the therapeutic efficacy ...
Histamine therapeutic efficacy in metastatic melanoma : role of histamine H4 receptor agonists and opportunity for combination with radiation
(Impact Journals, 2017)
Abstract: The aims of the work were to improve our knowledge of the role of H4R in melanoma proliferation and assess in vivo the therapeutic efficacy of histamine, clozapine and JNJ28610244, an H4R agonist, in a preclinical ...
Possible efficacy of hydroxychloroquine on accelerated nodulosis during methotrexate therapy for rheumatoid arthritis [1]
This letter shows some possible efficacy of hydroxychloroquine on accelerated nodulosis during methotrexate therapy for rheumatoid arthritis, Arthritis, Rheumatoid/complications,Arthritis, Rheumatoid/drug therapy; Humans; ...
Potential therapeutic agents against COVID-19 based on blocking and inhibition of the viral life cycle and the cytokine storm syndrome
(EFACIM. Editorial de la Facultad de Ciencias Médicas - Universidad Nacional de Asunción, 2020)
Autoeficácia, catastrofização da dor e qualidade de vida em indivíduos com fibromialgia
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Enfermagem - PPGEnfCâmpus São Carlos, 2015-02-27)
Fibromyalgia is defined as a syndrome characterized by chronic widespread musculoskeletal pain associated with a range of symptoms, including, sleep disturbances, fatigue, and emotional dysfunction are particularly frequent. ...
Monepantel pharmaco-therapeutic evaluation in cattle: Pattern of efficacy against multidrug resistant nematodes
(Elsevier, 2021-04)
The goal of the current work was to perform an integrated evaluation of monepantel (MNP) pharmacokinetics (PK) and pharmacodynamics, measured as anthelmintic efficacy, after its oral administration to calves naturally ...
Structure-function analysis and therapeutic efficacy of antibodies to fungal melanin for melanoma radioimmunotherapy
(2018)
Metastatic melanoma remains difficult to treat despite recent approvals of several new drugs. Recently we reported encouraging results of Phase I clinical trial of radiolabeled with 188Re murine monoclonal IgM 6D2 to melanin ...