Buscar
Mostrando ítems 61-70 de 90
Neuroprotective effects of the catalytic subunit of telomerase : A potential therapeutic target in the central nervous system
(2016-07-01)
Senescence plays an important role in neurodegenerative diseases and involves key molecular changes induced by several mechanisms such as oxidative stress, telomere shortening and DNA damage. Potential therapeutic strategies ...
Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan
(WILEY-BLACKWELL PUBLISHING, INC, 2008)
Large, long-lived species experience more lifetime cell divisions and hence a greater risk of spontaneous tumor formation than smaller, short-lived species. Large, long-lived species are thus expected to evolve more elaborate ...
Alteraciones en el material genético de pintores de carros expuestos a solventes orgánicos en una localidad de Bogotá
(Universidad del RosarioFacultad de medicina, 2015)
Organic solvents are chemicals that their physicochemical properties are easily inhaled or absorbed through the skin, can cause varying degrees of damage on health. In Colombia there are regulations covering the protection ...
Comprimento do telômero e curso de vida: relações com condições de saúde, marcadores inflamatórios e desempenho físico em idosas da comunidade
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM FISIOTERAPIA, 2016-11-25)
Introduction: Telomere length (TL) has been pointed out as a possible biomarker of cellular aging, as its physiological size progressively shortens with the course of cellular replications. In addition to this physiological ...
Low Oct4 expression in mesenchymal stem cells contributes to the development of the bone marrow pre-metastatic niche in advanced breast cancer patients
(Fundación Revista Medicina, 2021)
The imbalance between osteogenesis and osteoclastogenesis in the bone marrow (BM) microenvironment seems to play an essential role in the establishment of bone metastasis in untreated advanced breast cancer patients (BCP). ...
Modelagem lógica de senescência celular humana
(Universidade Federal de Santa MariaBRFísicaUFSMPrograma de Pós-Graduação em Física, 2012-12-12)
After the progressive telomere shortening in successive cell divisions, normal
somatic cells undergo a growth arrest called cellular senescence that occurs due to
incomplete DNA replication. Senescence can also be activated ...
The links between osteoporosis and sarcopenia in women
(Springer, 2019)
The world population is aging, so it is not uncommon that diseases associated with old age are steadily increasing. Osteoporosis and sarcopenia are two disorders that seriously impair the quality of life in the elderly. ...
Tumor-induced senescent T cells with suppressor function: A potential form of tumor immune evasion
(American Association for Cancer Research, 2008-02)
Senescent and suppressor T cells are reported to be increased in select patients with cancer and are poor prognostic indicators. Based on the association of these T cells and poor outcomes, we hypothesized that tumors ...