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Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest
Many environmental and physiological stresses are chronic. Thus, cells are constantly exposed to diverse types of genotoxic insults that challenge genome stability, including those that induce oxidative DNA damage. However, ...
Detection of excision repaired DNA damage in the comet assay by using Ara-C and hydroxyurea in three different cell types
(Springer, 2009-02)
Because of its characteristics, the comet assay has been used to evaluate the ability of virtually any type of eukaryotic cell to repair different kinds of DNA damage, including double and single strand breaks and base ...
Protective effects of mate tea (Ilex paraguariensis) on H2O2-induced DNA damage and DNA repair in mice
(Oxford, 2008)
Yerba mate (Ilex paraguariensis) is rich in several bioactive compounds that can act as free radical scavengers. Since oxidative DNA damage is involved in various pathological states such as cancer, the aim of this study ...
Structural Basis of Importin-alpha-Mediated Nuclear Transport for Ku70 and Ku80
(Academic Press Ltd Elsevier B.V. Ltd, 2011-09-16)
Ku70 and Ku80 form a heterodimeric complex involved in multiple nuclear processes. This complex plays a key role in DNA repair due to its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologous ...
Structural Basis of Importin-alpha-Mediated Nuclear Transport for Ku70 and Ku80
(Academic Press Ltd Elsevier B.V. Ltd, 2011-09-16)
Ku70 and Ku80 form a heterodimeric complex involved in multiple nuclear processes. This complex plays a key role in DNA repair due to its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologous ...
Evolution and mechanism of the mitochondrial cox1 intron horizontal transfer in Angiosperms
(Canadian Society of Plant Biologists, 2017)
The most frequent case of horizontal gene transfer in angiosperms involves the group I intron in the cox1 mitochondrial gene, originally acquired from a fungal donor and followed by more than 100 subsequent inferred ...
Biflorin induces cytotoxicity by DNA interaction in genetically different human melanoma cell lines
(Pergamon-Elsevier Science Ltd, 2016)
Cancer is a public health problem and the second leading cause of death worldwide. The incidence of cutaneous melanoma has been notably increasing, resulting in high aggressiveness and poor survival rates. Taking into ...
Methylation of the nonhomologous end joining repair pathway genes does not explain the increase of translocations with aging
(Springer, 2014-11-16)
Chromosome translocations are especially frequent in human lymphomas and leukemias but are insufficient to drive carcinogenesis. Indeed, several of the so-called tumor specific translocations have been detected in peripheral ...