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Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation
(Public Library Science, 2015)
Primary Cilia (PC) are a very likely place for signal integration where multiple signaling pathways converge. Two major signaling pathways clearly shown to signal through the PC, Sonic Hedgehog (Shh) and PDGF-Ra, are ...
Estudo da via de sinalização Sonic Hedgehog em carcinomas de mama.
(MedicinaColegiado do Curso de Graduação em MedicinaUFBAbrasil, 2013-11-06)
A via de sinalização Hedgehog (HH) desempenha papel importante no desenvolvimento embrionário influenciando, de forma autócrina e parácrina: a proliferação, diferenciação e morfologia das células. A ativação desta via tem ...
Heterotrimeric Gi Proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration
(American Society For Biochemistry And Molecular Biology, 2011-07)
Evidence supporting the functionality of Smoothened (SMO), an essential transducer in most pathways engaged by Hedgehog (Hh), as a Gi-coupled receptor contrasts with the lack of an apparently consistent requirement for Gi ...
Irradiated Riboflavin Diminishes the Aggressiveness of Melanoma In Vitro and In Vivo
(Public Library ScienceSan FranciscoEUA, 2013)
Sonic hedgehog (Shh)/Gli modulates the spatial organization of neuroepithelial cell proliferation in the developing chick optic tectum
(2012)
BACKGROUND: Sonic hedgehog (Shh)/Gli pathway plays an important regulatory role on the neuroepithelial cells (NEc) proliferation in the dorsal regions of the developing vertebrate Central Nervous System. The aim of this ...
Sonic Hedgehog modulates EGFR dependent proliferation of neural stem cells during late mouse embryogenesis through EGFR transactivation
(2013)
Sonic Hedgehog (Shh/GLI) and EGFR signaling pathways modulate Neural Stem Cell (NSC) proliferation. How these signals cooperate is therefore critical for understanding normal brain development and function. Here we report ...
Proliferation of murine midbrain neural stem cells depends upon an endogenous Sonic Hedgehog (Shh) source.
(2013)
The Sonic Hedgehog (Shh) pathway is responsible for critical patterning events early in development and for regulating the delicate balance between proliferation and differentiation in the developing and adult vertebrate ...
Proliferation of murine midbrain neural stem cells depends upon an endogenous Sonic Hedgehog (Shh) source.
(2013)
The Sonic Hedgehog (Shh) pathway is responsible for critical patterning events early in development and for regulating the delicate balance between proliferation and differentiation in the developing and adult vertebrate ...
Evaluación de Neogenina-1 como efector de la vía Sonic Hedgehog en Carcinoma Basocelular.
El Carcinoma Basocelular Cutáneo (BCC), un tipo de cáncer de piel, es una de las neoplasias más frecuentes en el ser humano. Es causado por una desregulación de la vía Sonic Hedgehog/Gli (Shh/Gli), cuya señalización juega ...