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Antiplatelet activity and TNF-α release inhibition of phthalimide derivatives useful to treat sickle cell anemia
(2019-08-01)
Sickle Cell Anemia (SCA) is one of the most prevalent hereditary hematological diseases worldwide. The disease is characterized by chronic inflammation, hypercoagulable state, and pro-thrombotic profile, which lead the ...
Synthesis and pharmacological evaluation of pomalidomide derivatives useful for sickle cell disease treatment
(2021-09-01)
Fetal hemoglobin (HbF) induction constitutes a valuable and validated approach to treat the symptoms of sickle cell disease (SCD). Here, we synthesized pomalidomide–nitric oxide (NO) donor derivatives (3a–f) and evaluated ...
Systemic lupus erythematosus in patients with sickle cell disease
(SpringerNew YorkEUA, 2008)
Benefits of kinesiotherapy and aquatic rehabilitation on sickle cell anemia. A case report
(Funpec-editora, 2010-01-01)
The process of hemoglobin polymerization and the consequent sickling of red blood cells that occurs in patients with sickle cell disease shortens the half-life of red blood cells. It causes vaso-occlusive complications, ...
Sickle cell anemia: delayed diagnosis in Bahia, Brazil-a largely Afro-descendant population
(International Society on Hypertension in Blacks, 2017)
Sickle cell disease on children: a descriptive study
(Brasil, 2012)
Aim: We intend to describe the socioeconomic and demographical characteristics of children between the ages of 0 and 11 years old, diagnosed with sickle cell disease, and describe the attention given to these children in ...
UHPLC Quantitation Method and In vitro Studies of Two New Phthalimide Derivatives Planned to Treat Sickle Cell Disease
(Bentham Science Publ Ltd, 2017-01-01)
Background: Sickle cell disease is characterized by the occurrence of acute disability and progressive organ damage, and it is one of the most common and severe monogenic disorders around the world. Since hydroxycarbamide ...